You are here

Akut Böbrek Yetmezliği ve Sarılıkla Başvuran Bir Hastada Leptospiroz

Leptospirosis in a Patient With Acute Renal Failure and Jaundice

Journal Name:

Publication Year:

Keywords (Original Language):

Abstract (2. Language): 
Leptospirosis is a re-emerging infectious disease, affecting both animals and humans worldwide. Multiple organ involvement may be encountered in leptospirosis. Renal involvement is very common. We describe the patient with Weil's syndrome from central Anatolia in Turkey who presented with renal failure and jaundice. Illust¬rating the medical history, initial findings and clinical course, we po¬int out the importance and difficulties of early diagnosis and treat¬ment. This case indicates that leptospirosis presenting with renal fa¬ilure is a severe disease. The association of acute renal failure and jaundice should lead the clinician to suspect leptospirosis. Leptospirosis may be associated with mesangioproliferative glomerulonephritis most likely mediated by immune complexes, interstitial nephritis, or acute renal failure resulting from acute tubular necrosis.
Abstract (Original Language): 
Leptospiroz tüm dünyada görülen, insan ve hayvanları etkileyen infeksiyöz bir hastalıktır. Multipl organ tutulumu olabilir. Renal tutulum bu hastalıkta sıktır. Bu yazıda sarılık ve böbrek yetmezliği ile başvuran, Weil send-romu tanısı konan bir hastanın klinik özellikleri, erken tanı ve teda¬vinin önemi ve zorlukları anlatılmıştır. Leptospiroz şiddetli böbrek yetmezliği ile ortaya çıkabilir. Sarılıklı ve böbrek yetmezlikli hastada klinisyen leptospirozdan şüphelenmelidir. Leptospiroz, immün komplekslere bağlı mezangiyoproliferatif glomerülonefrit, interstis-yel nefrit veya akut tübüler nekroz ve sonucunda akut böbrek yet¬mezliğine neden olabilir.
FULL TEXT (PDF): 

REFERENCES

References: 

1. Covic A, Goldsmith DJ, Gusbeth-Tatomir P, Seica A, Covic M. A retrospective 5-year study in Moldova of acute renal failure due to leptospirosis: 58 cases and a review of the literature.
Nephrol Dial Transplant 2003;18(6):1128-34. Review.
2. Yang CW, Wu MS, Pan MJ. Leptospirosis renal disease. Nephrol Dial Transplant 2001;16:73-7.
3. Chugh KS, Sitprija V, Jha V. Acute renal failure in the tropical countries. In: Davison AM, Cameron JS, Grünfeld JP, Ponticelli C, Ritz E, Winerals CG, van Ypersele C. Oxford Clinical Nephrology. 3rd Edition. Oxford University Press Inc. New York 2005, pp:1614-30.
4. Feigin RD, Anderson DC. Human leptospirosis. Crit Rev Clin Lab Sci. 1975;5(4):413-67.
5. Yang CW, Pan MJ, Wu MS, Chen YM, Tsen YT, Lin CL, Wu
CH, Huang CC. Leptospirosis: an ignored cause of acute re¬nal failure in Taiwan. Am J Kidney Dis 1997;30(6):840-5.
6. Niwattayakul K, Homvijitkul J, Niwattayakul S, Khow O, Sitprija V. Hypotension, renal failure, and pulmonary comp¬lications in leptospirosis. Ren Fail 2002;24(3):297-305.
7. Muthusethupathi MA, Shivakumar S, Vijayakumar R, Jayaku-mar M. Renal involvement in leptospirosis—our experience
in Madras City. J Postgrad Med 1994;40(3):127-31.
8. Nicholson GD, Edwards CN, Hassell TA, Everard CO, Cal-
lender J. Urinary diagnostic indices in the management of leptospirosis. Selection of patients for dialysis therapy. West
Indian Med J 1989;38(1):33-8.
9. Chugh KS, Jha V. Other bacterial, viral, parasitic, and fun¬gal infections. In: Massry SG, Glassock RJ. Textbook of Nephrology. 4th Edition. Lippincott Williams & Wilkins,
Philadelphia 2001, pp:684-94.
10. Everard JD, Everard COR. Leptospirosis in the Caribbean.
Reviews in Medical Microbiology 1993;4:114-22.
11. Terpstra WJ, Ligthart GS, Schooner GI. ELISA for the detec¬tion of specific IgM and IgG in human leptospirosis. Jour¬nal of General Microbiology 1985;131:377-85.
12. Petros S, Leonhardt U, Engelmann L. Serum procalcitonin and proinflammatory cytokines in a patient with acute se¬vere leptospirosis. Scand J Infect Dis 2000;32(1):104-5.

Thank you for copying data from http://www.arastirmax.com