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Hemodiyaliz Hastalarının Sitokin Düzeyleri ve Oksidatif Stres ile İlişkisi

The Cytokine Levels in Hemodialysis Patients and Relationship With Oxidative Stress

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2007

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Hemodialysis (HD) treatment is almost associated with oxidative stress. In this study, we tried to investigate the relationship between oxidative stress and cytokine levels in patients undergoing hemodialysis treatment. Eighteen HD patients aged 21-70 years (47+14) and 12 healthy subjects were included in this study. We measured plasma levels of malondialdehyde (MDA) as a marker of lipid peroxidation, protein carbonyl (PC) content as a marker of protein oxidation, protein sulfhydryl groups (SH) as an important chain-break antioxidant and interleukin (IL1-2, IL-8, IL-10 and tumor necrosis factor-ct (TNF-«) in dialysis patients and controls. The level of MDA and PC increased when compared to the controls (p<0.001, p<0.05); however, the levels of SH groups were lower in HD patients (p<0.01). Plasma IL-2, IL-8 and TNF-a levels were found to be higher than controls (p<0.05; p<0.05, p<0.001, respectively); however, interleukin-10 levels were lower (p<0.05). There is no significant correlation between cytokines and oxidative stress markers. We conclude that HD treatment is associated with increased oxidative damage and cytokine levels but there is no correlation between them.
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Abstract (Original Language): 
Bu çalışmada, hemodiyaliz tedavisi gören hastalarda oksidatif stres ile sitokin seviyeleri arasındaki ilişkinin araştırılması planlanmıştır. Yaşları 21-70 (47+14) arasında değişen 18 HD hastası ve 12 sağlıklı kişi çalışmaya alındı. Hastalar ve kontrol gruplarından elde edilen plazma örneklerinde lipid peroksidasyonunun bir göstergesi olarak malondialdehid (MDA) seviyesi, protein oksidasyonunun bir göstergesi olarak protein karbonil (PK) içeriği, plazma antioksidan kapasitesinin bîr göstergesi olarak da total sülfidril grupları (SH) ve interlökin (IL)-2, IL-8, IL-10, TNF-a seviyeleri ölçüldü. Hemodiyaliz hastalarında plazma MDA ve PK konsantrasyonları kontrol grubu ile kıyaslandığında daha yüksek bulunurken (p<0.001, p<0.05), SH gruplarının seviyesi düşük bulundu ip<0.01). Plazma IL-2, IL-8 ve TNF-n seviyeleri yüksek bulunmasına karşın (sırasıyla p<0.05; p<0.05, p<0.001), IL-10 seviyeleri düşük bulundu (p<0.05). Sitokin seviyeleri ve oksidatif stres belirteçleri arasında istatistiksel olarak anlamlı bir korelasyon bulunmamıştır. Hemodiyaliz tedavisi gören kronik böbrek yetmezlikli hastalarda oksidatif hasar ve sitokin düzeyleri artarken, aralarında bir ilişkiye rastlanmamıştır.
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  • 3
129-134
  • Turkish

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Türk Nefroloji Diyaliz ve Transplantasyon Dergisi /Official Journal of the Turkish Society of Nephrology
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