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Mikroalbüminürisi Olan Esansiyel Hipertansif Hastalarda Plazma Total Homosistein Düzeyleri ve Diğer Kardiyovasküler Risk Faktörleri

Plasma Total Homocysteine Levels and Other Cardiovascular Risk Factors in Essentially Hypertensive Patients With Microalbuminuria

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2007

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Keywords (Original Language):

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Abstract (2. Language): 
The aim of the present study was to investigate the plasma total homocysteine levels and other risk factors for cardiovascular disease in microalbuminuria essentially hypertensive patients and to compare with those of non-microalbuminuric ones. Plasma total homocysteine levels were determined in essentially hypertensive patients (n=45) and compared with those of the controls (n=14). Then, the patient group was divided into two subgroups as microalbuminuric and non-mtcroalbuminuric. Both subgroups were also compared to each other with respect to determined parameters including plasma total homocysteine levels. Plasma total homocysteine levels of the patients (12.5+6.58 pmol/L) were lower, but not significantly (p=0.795), than those of the controls (13.28+11.11 umol/L). Microalbuminuric (12.82+6.01 pmol/L) and non-microalbuminuric (12.06±7.45 pmol/L) patients did not show a statistically significant difference from each other with respect to plasma total homocysteine levels. Similarly, plasma total homocysteine levels were also not different between the patients with and without hypertensive retinopathy in the main (p=0.648), microalbuminuric (p=0.721) and non-microalbuminuric (p=0.246! patient groups. However, serum LDL cholesterol levels of microalbuminuric patients (111.76+30.10 mg/dL) were significantly higher than those of the non-microalbuminuric patients (87.43+30.39 mg/dL) (p=0.037). It suggests that plasma total homocysteine levels do not involve in the pathogenesis of microalbuminuria and retinopathy in patients with essential hypertension, but microalbuminuria in these patients seems to be affected by serum LDL cholesterol level
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Abstract (Original Language): 
Bu çalışmanın amacı, mikroalbüminürisi olan esansiyel hipertansiyonla hastalardaki plazma total homosistein düzeyleri ile kardiyovasküler hastalık için diğer risk faktörlerini araştırmak ve bu verileri mikroalbüminürik olmayanlarınkilerle karşılaştırmaktı. Esansiyel hipertansif hastalarda <n=45l plazma total homosistein düzeyleri belirlendi ve kontrollerinki ln=14l ile kıyaslandı. Daha sonra, hasta grubu mikroalbüminürik olanlar ve olmayanlar olmak üzere iki al! gruba bölündü. Her iki alt grup birbiriyle -plazma total homosistein düzeylerini de içeren- çalışılan parametreler açısından kıyaslandı. Hastaların plazma total homosistein düzeyleri (12.5±6.58 pmol/U kontrollerinkinden (13.28*11.11 umoi/L) daha düşüktü; fakat fark anlamlı değildi (p=0.795). Mİkroalbüminürik olan (12.82±6.01 pmol/L) ve olmayan (12.06±7.45 pmol/L) hastalar, plazma total homosistein düzeyleri bakımından birbirlerinden istatistiksel olarak anlamlı bir farklılık göstermediler. Benzer şekilde, gerek ana grupta (p=0.648) gerekse mikroalbüminürik olan (p=0.721) ve olmayan (p=0.246) hasta gruplarında, hipertansif retinopatisi olan ve olmayan hastalar arasında da plazma total homosistein düzeyleri farklı değildi. Ancak, mikroalbüminürik hastaların serum LDL kolesterol düzeyleri (111.76+30.10 mg/dU mikroalbüminürik olmayan hastalarınkinden (87.43±30.39 mg/dü anlamlı olarak (p=0.037) daha yüksekti. Verilerimiz, plazma total homosistein düzeylerinin esansiyel hipertansiyonlu hastalardaki mikroalbüminüri ve retinopatinin patogenezinde bir rolü olmadığı İzlenimini vermektedir; fakat bu hastalardaki mikroalbüminüri serum LDL kolesterol düzeylerinden etkilenmiş görünmektedir
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  • Turkish

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Official Journal of the Turkish Society of Nephrology / Türk Nefroloji Diyaliz ve Transplantasyon Dergisi
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