You are here

Home » Content

Canlı Böbrek Vericilerinin Uzun Dönemde Karşılaşabileceği Riskler

Long-term Risks in Living Kidney Donors

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2007

Key Words:

Keywords (Original Language):

Author Name
Abstract (2. Language): 
The aim of this study is to evaluate the long-term follow-up (>5 years) of the living-related donors in our center. Out of 149 living-related donors who were at least 5 years out of donor nephrectomy, 92 {62%) patients participated in the study. The mean follow-up period was 110+31.4 months. The mean age of the donors during operation and at the last follow-up was 51+13.2 years and 59.5±11.3 years, respectively. M/F ratio was 0.58. The mean SCr levels and CrCI rates pre-donation and at the last follow-up were 0.95±0.2 mg/dl vs. 0.97+0.18 mg/dl <p=0.42), and 103.5+26.1 ml/min vs. 81.1+25 ml/min (p=0.001), respectively. SCr levels and CrCI were within normal limits in all patients at pre-donation and at the last follow-up. There was significant differences in mean diastolic pressure (p=0.02) at pre-donation and at the follow-up. Proteinuria and microalbuminuria were negative at pre-donation. Proteinuria (n=5), microalbuminuria (n=3) detected at the last follow-up. Renal function remained within normal limits in all patients after donation. Proteinuria and microalbuminuria rates, as well as the percentage of donors with hypertension are not more than what is seen in general population. Other diseases, benign or malignant, are detected earlier In organ donors, if they are compliant with the follow-up protocols as was the case in our series
Bookmark/Search this post with
Abstract (Original Language): 
Çalışmanın amacı en az beş yıl takipli canlı böbrek vericilerinin uzun dönem takip sonuçlarını değerlendirmektir. Donör nefrektomi sonrası en az beş yıl takipli 149 böbrek vericisinden 92'si (%62) çalışmaya dahil edildi. Ortalama takip süresi 110±31.4 ay idi. Vericilerin ortalama yaşı ameliyat ve son takipte sırasıyla, 51±13.2 ve 59.5+11.3, erkek/kadın oranı ise 0.58 idi. Ameliyat öncesi ve son takipte ortalama serum kreatinin (SCr) ve kreatinin klirens (CrCI) değerleri sırasıyla 0.95±0.2 mg/dl, 0.97±0.18 mg/dl (p=0.42), ve 103.5±26.1 ml/dak, 81.1+25 ml/dak lp=0.001) idi. SCr değerleri ve CrCI tüm vericilerde çalışma süresinde normal sınırlar içerisindeydi. Ortalama diyastolik kan basıncı değerleri son takipte anlamlı olarak yüksek saptandı (p=0.02). Proteinüri ve mikroalbüminüri ameliyat öncesi tüm vericilerde negatifti. Son takipte proteinüri (n=5), mikroalbüminüri (n=3) saptandı. Tüm vericilerde ameliyat sonrası böbrek fonksiyonları normal sınırlar İçindeydi. Proteinüri ve mikroalbüminüri oranları ve hipertansiyon sıklığı normal popülasyona benzer oranlardaydı. Ortaya çıkabilecek benign veya malign hastalıkların erken tanısı takip protokollerine uyumlu vericilerde mümkün olmaktadır.
FULL TEXT (PDF): 
PDF icon arastrmx_172977_16_pp_183-186.pdf
  • 4
183-186
  • Turkish

REFERENCES

References: 

1. Taghavi R, Does kidney donation threaten the quality of life of the donor? Transplant Proc 1995;27:2595-6.
2. Melchor JL, Gracida C, Lopez A. Living donors in kidney transplantation: Five-year follow-up. Transplant Proc 1998;30:2869-70.
3. Gossmann J, Wilhdm A, Kachel HG, et al. Long-term consequences of live kidney donation follow-up in 93% of living kidney donors in a single transplant center. Anı J Transplant 2005;5:2417-2424.
4. Goldfarb DA, Matin SF, Braun WE, et al. Renal outcome 25 years after donor nephrectomy. J Urol 2001;166:2043-7.
5. Fehrman-Ekholm 1, Duner F, Brink B, Tyden G, Flincler CG. No evidence of accelerated loss of kidney function in living kidney donors: results from a cross-sectional follow-up. Transplantation 2001 ;72(3):444-449.
6. Siebels M, Theodorakis J, Schmeller N, et al. Risks and complications in 160 living kidney donors who underwent nephroureterectomy. Nephrol Dial Transplant 2003;18:2648-2654.
7. Najarian JS, Chavers BM, McHugh LE, Matas AJ. 20 years or more of follow-up of living kidney donors. Lancet 1992;340:807-810.
8. Matas AJ, Barlett ST, Leichlman AB, Delmonico FL Morbidity and mortality after living kidney donation, 1999-2001: Survey of United States transplanl centers. Am J Transplant 2003;3:830-834.
9. Koçak B, Koffron AJ, Baker TB, et al. Proposed classification of complications after live donor nephrectomy. Urology 2006;67:927-931.
10. Undurraga A, Roessler E, Arcos Ü, et al. Long-term follow-up of renal donors, Transplant Proc 1998;30:2283-2285.
11. Anderson RG, Bueschen AJ, Lloyd LK, Dubovsky EV, Hums JR. Short-term and long-term changes in renal function after donor nephrectomy. J Urol 1991;145:11-13-
12. Saran R, Marshall SM, Madsen R, Keavey F, Tapson |S. Long-term follow-up of kidney donors: a longitudinal study. Nephrol Dial Transplant 1997;12:1615-1621.
13- Fehnnan-Ekholm 1, Elindcr CG, Stenbeck M, Tyden G, Groth CG. Kidney donors live longer. Transplantation 1997;64:976-978.
14. Liounis B, Roy LP, Thompson JF, May J, Sheil AG. The living related kidney donor: a follow-up study. Med J Aust 1988;2:436-437.

Thank you for copying data from http://www.arastirmax.com