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Konvansiyonel veya İntensif İnsülin Tedavisi Gören Diyabetli Hemodiyaliz Hastalarında Biyokimyasal Parametreler

Analysis of Biochemical Markers in Diabetic Hemodialysis Patients on Conventional or Intensive Insulin Therapy

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2009

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Abstract (2. Language): 
OBJECTIVE: The objective of this study was to compare intensive and conventional insulin therapies with regards to HbA1c, serum lipids, and other biochemical markers. METHODS: This was a retrospective study investigating data from 44 insulin-dependent diabetic hemodialysis patients followed in our hemodialysis unit. Fifteen of the patients were on conventional therapy and 29 were on intensive therapy. RESULTS: Of the patients 34% were women, the mean age was 60±10 years, duration of diabetes 18±8 years and dialysis duration 3±2 years. Weight gain between dialysis sessions was 2570±768 g and dry weight was 64.6±1.3 kg. There was no significant difference between the two treatments in terms of HbA1c, CRP, hemoglobin, urea, creatinine, uric acid, albumin and electrolytes (p>0.05). Although total cholesterol and triglyceride levels were lower in the intensive treatment group than that conventional treatment grap the difference was not statistically significant (p>0.05). LDL and HDL levels were not statistically different between the study groups (p>0.05). CONCLUSIONS: There was no statistically significant difference between conventional and intensive insulin treatments in terms of HbA1c or other biochemical markers.
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Abstract (Original Language): 
AMAÇ: Bu çalışmanın amacı, intensif ve konvansiyonel insülin tedavi yöntemlerinin, HbA1c düzeyi, serum lipidleri ve diğer biyokimyasal parametreler yönünden karşılaştırılmasıdır. YÖNTEM: Çalışma, hemodiyaliz ünitemizde takip edilmekte olan 44 insülin bağımlı diyabetik hemodiyaliz hastasının verileri retrospektif incelenerek gerçekleştirildi. Hastaların 15’i konvansiyonel, 29’u intensif tedavi görüyordu. BULGULAR: Hastaların %34’ü kadın, ortalama yaş 60±10 yıl, ortalama diyabet süresi 18±8 yıl, ortalama diyaliz süresi 3±2 yıldı. Diyaliz arası kilo alım ortalamaları 2570±768 g, kuru ağırlıkları 64.6±1.3 kg bulundu. İnsülin kullanım şekline göre HbA1c, CRP, hemoglobin, üre, kreatinin, ürik asit, albumin ve elektrolitler arasında istatistiksel olarak anlamlı bir farklılık bulunmadı (p>0.05). İntensif insülin kullanan olguların total kolesterol ve trigliserid düzeyleri, konvansiyonel insülin kullanan olgulardan daha düşük olmakla birlikte fark istatistiksel olarak anlamlı değildi (p>0.05). LDL ve HDL düzeyleri arasında istatistiksel olarak anlamlı bir farklılık bulunmadı (p>0.05). SONUÇ: Konvansiyonel ve intensif insülin tedavileri arasında HbA1c de dahil olmak üzere biyokimyasal değerler yönünden anlamlı farklılık bulunmadı.
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  • 1
15-19
  • Turkish

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ÖĞÜTMEN: Diyabetli Hemodiyaliz Hastalarında
Konvansiyonel veya İntensif İnsülin Tedavisi
Cilt/Vol. 18, No, 1, 2009 Sayfa/Page 15-19
18
Türk Nefroloji Diyaliz ve Transplantasyon Dergisi
Turkish Nephrology, Dialysis and Transplantation Journal
19
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ÖĞÜTMEN: Diyabetli Hemodiyaliz Hastalarında
Konvansiyonel veya İntensif İnsülin Tedavisi
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