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Kronik Periton Diyalizi Hastalarında Kemik Mineral Dansitesi ile Vitamin D Düzeyleri Arasındaki İlişki

Relationship Between Bone Mineral Density and Vitamin D Levels in Patients Undergoing Chronic Peritoneal Dialysis

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2009

Key Words:

Keywords (Original Language):

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Abstract (2. Language): 
Low bone mineral density (BMD) is one of the risk factors for bone fracture. The incidence of bone fracture is highest among patients with chronic renal failure. There is little data about the BMD of patients undergoing chronic peritoneal dialysis (PD). In addition, dialysis patients with low vitamin D levels are at increased risk of early mortality. We investigated the incidence of osteopenia/osteoporosis and relationship between BMD and vitamin D levels in 28 peritoneal dialysis patients. Bone densitometry was studied by dual-energy x-ray absorptiometry (DEXA). Bone mass was classified as normal, osteopenic, or osteoporotic according to World Health Organization criteria. Serum 25-hydroxyvitamin D (25OHD) levels were measured in all patients. Of the 28 patients, 25.7% had osteoporosis and 27.9% had osteopenia. Mean 25OHD levels were 50.4±28 nmol/L. Twelve patients (42.9%) had vitamin D insufficiency, eight (28.6%) had vitamin D deficiency and three (10.7%) had severe deficiency. In conclusion, these results indicated that 53.6% of our chronic PD patients have subnormal bone mass. In addition, vitamin D insufficiency and deficiency are very common in peritoneal dialysis patients.
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Abstract (Original Language): 
Kemik mineral dansitesinin (KMD) düşüklüğü kemik fraktürünün risk faktörlerinden biridir. Kemik fraktürü sıklığı, kronik böbrek yetersizliği olan hastalarda çok yüksektir. Kronik periton diyalizi (PD) hastalarında KMD ile ilgili az sayıda çalışma vardır. Ayrıca, diyaliz hastalarında vitamin D seviyelerindeki düşüklüğün erken mortalite ile ilişkili olduğu ileri sürülmüştür. Biz 28 kronik PD hastasında osteopeni/ osteoporoz sıklığını ve vitamin D seviyeleri ile KMD arasındaki ilişkiyi araştırdık. Kemik dansitesi dual-energy X-ray absorptiometry (DEXA) ile ölçüldü. Kemik kütlesi, Dünya Sağlık Örgütü kriterlerine göre normal, osteopenik ve osteoporotik olarak sınıflandırıldı. Tüm hastalarda serum 25- hidroksivitamin D (25OHD) düzeyleri ölçüldü. Yirmi sekiz hastanın %25.7’sinde osteoporoz, %27.9’unda osteopeni saptandı. Ortalama serum 25OHD seviyeleri 50.4±28 nmol/L idi. On iki (%42.9) hastada vitamin D azlığı, sekiz (%28.6) hastada vitamin D yetersizliği ve üç (%10.7) hastada şiddetli eksiklik tespit edildi. Sonuç olarak, bulgularımız hastalarımızın %53.6’sında kemik kütlesinin subnormal düzeylerde olduğunu göstermektedir. Ayrıca, vitamin D eksikliği ve yetersizliği kronik periton diyalizi hastalarında oldukça sıktır.
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