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Bir Renal Transplant Hastasında Everolimusa Bağlı Nefrotik Düzeyde Proteinüri

Nephrotic Range Proteinuria Due to Everolimus in a Renal Transplant Recipient

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Abstract (2. Language): 
Survival of transplant recipients strongly depends on the success of the immunosuppressive regimen. Many immunosuppressive drugs such as calcineurin inhibitors (CNIs) and purine biosynthesis inhibitors (mycophenolic acids) are used after renal transplantation. Everolimus is a new agent which is a proliferation signal inhibitor (PSI)/ mammalian target of rapamycin inhibitor that is structurally similar to sirolimus. Everolimus has adverse effects associated with dose-related class actions including proteinuria. Proteinuria due to sirolimus has been reported previously but there are only a few publications about everolimus. Here, we report a case with severe proteinuria due to everolimus which developed three months after transplantation.
Abstract (Original Language): 
Transplant hastalarının yaşam süresinde immünsupresif ajan seçimi büyük önem taşır. Kalsinörin inhibitörü ve pürin biyosentez inhibitörü gibi bir çok immünsupresif ilaç renal transplantasyon sonrasında kullanılır. Everolimus bu amaçla kullanılan yeni bir ajandır. Everolimus sirolimus gibi proliferasyon sinyal inhibitörüdür. Doza bağlı olarak spesifik yan etkileri vardır. Bunlardan bir tanesi de proteinüridir. Literatürde proliferasyon signal inhibitörü olarak etki gösteren sirolimus ile ilgili nefrotik düzeyde proteinüri geliştiğini gösteren raporlar olduğu bilinmektedir. Ancak aynı etki mekanizmasına sahip ve yeni jenerasyon bir immünsupresif ajan olan everolimus ile ilgili proteinüri geliştiğini gösteren bilgi nadirdir. Biz bu yazıda transplantasyondan 3 ay sonra everolimusa bağlı şiddetli proteinüri gelişen vakayı sunuyoruz.
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