Methotrexate-induced Pancytopenia in Two Patients with Renal Dysfunction
Journal Name:
- Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi
Keywords (Original Language):
| Author Name | University of Author | Faculty of Author |
|---|---|---|
Abstract (2. Language):
Methotrexate (MTX) is cleared primarily by renal excretion. The excretion of MTX is delayed in
subjects with renal dysfunction and elevated plasma MTX concentrations develop which lead to bone
marrow toxicities and possible pancytopenia. In this case report, we presented two advanced age patients
with MTX-induced pancytopenia. The first patient on hemodialysis was diagnosed with seronegative
arthritis while the second patient with congestive heart failure was diagnosed with rheumatoid arthritis
and both of them were given treatment with a low dose of MTX (7.5 mg/week),
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Abstract (Original Language):
Birincil atılım yeri böbrekler olan Metotreksat (MTX) böbrek işlevleri bozuk olan olgularda plazmada
birikime uğramakta ve kemik iliğinde toksik etki yaparak pansitopeniye neden olabilmektedir. Bu olgu
raporunda, MTX kullanımına bağlı pansitopeni gelişen ileri yaşta iki olgu sunulmuştur. Hemodiyaliz
tedavisinde olan ilk olguya seronegatif artrit, konjestif kalp yetersizliği bulunan ikinci olguya romatoid
artrit tanısı kondu ve her iki olguya düşük doz MTX (7,5 mg/hafta) tedavisi verildi
FULL TEXT (PDF):
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