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İki Kardeşte Aynı Anda Ortaya Çıkan Henoch-Schönlein Purpurası

Simultaneous Occurrence of Henoch-Schonlein Purpura in Two Brothers

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2011
DOI: 
10.5262/tndt.2011.1002.17

Key Words:

Keywords (Original Language):

Author Name
Abstract (2. Language): 
Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis of childhood, but the etiology is not known. Familial occurrence of HSP is rare. There are only two previous reports of the simultaneous onset of HSP in siblings. Herein, we present simultaneous occurrence of HSP in two brothers. Nearly simultaneous onset of symptoms in our cases suggests that a common environmental factor, either infectious or allergic, is possible. Our patients were previously healthy, with no history of atopy. They had neither a history of infection prior to the onset of HSP nor clinical evidence of infection on admission, although antistreptolysin titers were elevated in both patients. The trigger causing HSP was not identified in these patients but we assumed that environmental factors may be responsible for the simultaneous occurrence of HSP in genetically susceptible patients.
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Abstract (Original Language): 
Henoch-Schönlein purpurası (HSP) nedeni tam olarak bilinmeyen, çocukluk çağının en sık görülen sistemik vaskülitidir. Ailesel HSP olguları nadirdir. Literatürde iki kardeşte aynı anda ortaya çıkan HSP sadece iki kez bildirilmiştir. Biz burada iki erkek kardeşte aynı gün ortaya çıkan HSP olgularını sunduk. Hastalarımızda bulguların neredeyse aynı anda başlamış olması ilk olarak enfeksiyöz veya alerjik nedenler gibi çevresel etkenleri akla getirdi. Hastalarımız daha öncesinde sağlıklı olup atopi öyküleri yok idi. Hastalarımızın her ikisinin de antistreptolizin titreleri yüksek saptandı. Ancak olgularda HSP başlangıcından önce enfeksiyon hikayesine veya başvurdukları anda klinik olarak enfeksiyon bulgusuna rastlanmadı. Biz bu kardeşlerde HSP’yi tetikleyen nedeni net olarak gösteremesek de genetik olarak duyarlı hastalarda çevresel etkenlerin rol oynayabileceğini düşündük.
FULL TEXT (PDF): 
PDF icon arastrmx_172977_20_pp_205-207.pdf
  • 2
205-207
  • Turkish

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