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Böbrek Nakli Alıcılarında Vitamin D Düzeyi ve Endotel İşlev Bozukluğu

Endothelial Dysfunction and Vitamin D Levels in Kidney Allograft Recipients

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2012
DOI: 
DOI 10.5262/tndt.2012.1001.09

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
There have been several studies demonstrating a relationship between vitamin D and cardiovascular disease. Vitamin D Deficiency/Insufficiency (D/I) is a common problem in chronic renal disease and also renal transplant recipients, however, there is a variation between the summer and winter periods. We investigated whether there is a relationship between vitamin D D/I and endothelial dysfunction in renal transplant recipients (RTR). We also evaluated vitamin D levels in summer and winter. Flowmediated dilatation (FMD), soluble endothelial protein receptor C (sEPRC) and soluble thrombomodulin (sTM) were chosen for markers of endothelial function. Firty-five patients were recruited to the study. Winter measurements were performed on March, summer measurements were performed in September. In the winter, methe an vitamin D level was 18.8±7.5, compared with 34.3±13.0 ng/ml in the summer period (p<0.0001). There were 38 (84%) and 20 (44%) patients in the winter and summer periods with vitamin D D/I, respectively. We did not find any significant association between vitamin D D/I and FMD, sTM or sEPCR in either period. While vitamin D D/I is a common finding during winter in RTR, it recovers in the summer. Moreover, vitamin D D/I seems not to be associated with endothelial dysfunction.
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Abstract (Original Language): 
Vitamin D düzeyi ile kardiyovasküler hastalıklar arasında ilişkiyi gösteren birçok çalışma vardır. Vitamin D yetersizliği/eksikliği kronik böbrek hastalıklarında ve böbrek nakli alıcılarında sık gözlenmekte ancak vitamin D düzeyi yaz ve kış aylarında değişiklikler göstermektedir. Biz bu çalışmada vitamin D yetersizlik/eksiklik ile endotel işlev bozukluğu arasında ilişkiyi değerlendirmeyi amaçladık. Yaz ve kış aylarında vitamin D düzeyi değerlendirildi. Endotel işlevleri akım aracılı vazodilatasyon ve çözünür endotel protein veseptörü C (sEPCR) ve çözünür thrombomodulin düzeyleri ile değerlendirildi. Çalışmaya 45 böbrek nakli alıcısı alındı ve kış ölçümü mart ayında ve yaz ölçümleri eylül ayında yapıldı. Kış çıkışı ortalama vitamin D düzeyi 18,8±7,5, yaz çıkışı ise 34,3±13,0 ng/ml olarak saptandı (p<0,0001). Kış ve yaz aylarında sırası ile 38 (%84) ve 20 (%44) vitamin D yetersiz/eksik hasta vardı. Her iki periyodda vitamin D yetersizlik/eksiklik ile akım aracılı vazodilatasyon, sTM veya sEPCR arasında bir ilişki yoktu. Sonuç olarak vitamin D yetersizlik/eksiklik kış aylarında böbrek nakli alıcılarında yaygın olarak gözlenirken yazın bu durum çoğu olguda düzelmektedir. Vitamin D yetersizlik/eksiklik ile endotel işlev bozukluğu arasında bir ilişki ortaya konulamamıştır.
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