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Böbrek Naklinin Geç Dönemde Kalp İşlevleri ve Yapısına Etkisi

Effects of Renal Transplantation on Cardiac Function and Morphology in the Late Posttransplant Period

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DOI: 
DOI 10.5262/tndt.2012.1001.05

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Abstract (2. Language): 
OBJECTIVE: To investigate the effects of renal transplantation on left ventricular (LV) function and morphology in patients with end-stage renal disease (ESRD) in the late posttransplant period. MATE RIAL and Methods: The prospective study included 40 patients (mean age 33.2 ± 7.7 years;25 female /15 male) with ESRD. In all of these patients, renal transplantation was performed successfully; and the serum creatinine levels were less than 2 mg/dL. The echocardiographic evaluations were performed before renal transplantation and 12. month after renal transplantation. Left ventricular diastolic diameter (LVDD), left ventricular systolic diameter (LVESD), left ventricular mass (LV Mass), left ventricular mass index (LVMI), LV ejection fraction (LVEF), Doppler and tissue Doppler parameters were obtained in all patients. Res ults: At the twelfth month, LVDD (48 ± 5 vs 45 ± 6, p: 0.01), LVSD (33 ± 4 vs 29 ± 4, p< 0.001) LVMI (114 ± 31 vs 98 ± 13, p: 0.007) decreased significantly compared to the pretransplant period. There was a significant increase in the LVEF in at the twelfth month (59 ± 5 vs 67 ± 6, p< 0.001). There was a significant improvement between pretransplant period and late posttransplant period with regard to diastolic cardiac function. ConclusI on: Renal transplantation had beneficial effects on diastolic and systolic functions and cardiac morphology in the late posttransplant period.
Abstract (Original Language): 
Amaç : Son dönem böbrek yetmezliği ile izlenen hastalarda nakil sonrası geç dönemde naklin sol ventrikül işlev ve yapısı üzerine etkisini araştırmayı planladık. GEREÇ ve YÖNTEMLER: 25 kadın /15 erkek olmak üzere 40 son dönem böbrek yetmezliği hastası ile yapılan bu ileri dönük çalışmada tüm hastalara başarılı bir şekilde böbrek nakli yapılmıştır (Tüm hastaların kreatin değerleri (<2mg/dl). Tüm hastalara nakil öncesi ve sonrası 12.ayda ekokardiyografik değerlendirme yapıldı. Bu ekokardiyografik incelemelerde tüm hastalarda sol ventriküler diastolik çap, sol ventriküler sistolik çap, sol ventrikül kitlesi, sol ventrikül kitle indeksi, sol ventriküler ejeksiyon fraksiyonu ayrıca doppler inceleme ve doku dopleri yapıldı. BUL GUL AR: On ikinci ayda, sol ventriküler diastolik çap (48 ± 5 vs 45 ± 6, p: 0.01), sol ventriküler sistolik çap (33 ± 4 vs 29 ± 4, p< 0.001) sol ventriküler kitle indeksi (114 ± 31 vs 98 ± 13, p: 0.007) nakil öncesi döneme göre anlamlı şekilde azalmıştır. Sol ventrikül ejeksiyon fraksiyonu on ikinci ayda anlamlı olarak artmıştır (59 ± 5 vs 67 ± 6, p< 0.001). Nakil öncesi döneme göre geç nakil sonrası dönemde diyastolik kardiyak işlevlerde anlamlı bir düzelme görülmektedir. Sonuç: Böbrek naklinin geç dönemde kardiyak yapı ve kalbin sistolik ve diyastolik işlevleri üzerine yararlı etkilerinin olduğu gösterilmiştir.

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