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Yeni Tanı Almış Tip 2 Diyabetik Hastalarda 24 Saatlik İdrarda Sodyum Atılımı ile İlişkili Olan Demografik, Klinik ve Laboratuvar Parametrelerin Değerlendirilmesi

Baseline Demographic, Clinical and Laboratory Parameters Related with 24 Hour Urinary Sodium Excretion in Newly Diagnosed Patients with Type 2 Diabetes

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DOI: 
DOI 10.5262/tndt.2013.1001.12

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Author NameUniversity of Author
Abstract (2. Language): 
OBJECTIVE: Hypertension is very frequently observed in patients with Type 2 diabetes. Increased salt intake has been shown to be related with elevated blood pressure. However, factors related with 24 hour urinary sodium (Na) excretion as a measure of Na intake is not specifically addressed in patients with newly diagnosed Type 2 diabetic patients. MA TERIAL and Metho ds: All patients underwent history taking, physical examination, blood pressure measurement, electocardiography, biochemical analysis, spot urine analysis, 24-hour urine collection to measure 24-hour urinary albumin, protein, sodium excretion and creatinine clearance. Res ults : In total, 114 patients were enrolled. Spearman correlation analysis revealed that 24-hour urinary Na excretion was correlated with body mass index (BMI) ( rho: 0.265, p: 0.004). blood urea nitrogen (rho: -0.210, p: 0.025) creatinine clearance (rho: 0.313, p: 0.001), albumin (rho: 0.320, p: 0.001), hemoglobin (rho: 0.242, p: 0.013) and triglyceride (rho: 0.261, p: 0.008). Linear regression of independent factors revealed that BMI (B: 0.013, CI: 0.004-0.022, P: 0.004), presence of smoking (B: 0.132, CI: 0.02-0.243, P: 0.021), creatinine clearance (B: 0.002, CI: 0.001-0.004, P: 0.012), and triglyceride levels (B: 0.017, CI: 0.009-0.056, P: 0.003) were related with logarithmically converted 24-hour Na excretion. Conclusio n: We demonstrated that BMI, creatinine clearance and serum triglyceride levels were independently associated with 24-hour urinary Na excretion in newly diagnosed Type 2 diabetic patients.
Abstract (Original Language): 
AMA Ç: Hipertansiyon Tip 2 diyabetli hastalarda sıklıkla görülen bir komplikasyondur. Bu hastalarda artmış tuz alımı hipertansiyon ile ilişkili bulunmuştur. Bununla birlikte literatürde tuz alımının bir göstergesi olarak 24 saatlik idrarda sodyum atılımını özellikle araştıran çalışmalar sınırlıdır. Biz bu çalışmamızda, yeni tanı almış tip 2 diyabetik hastalarda 24 saatlik idrarda sodyum atılımını etkileyen faktörleri araştırmayı amaçladık Gereç ve Yönte mler : Bütün hastaların tıbbı hikâyeleri alındı, fizik muayeneleri yapıldı, kan basınçları ölçüldü, elektrokardiografileri çekildi, biyokimyasal analizleri yapıldı, rutin idrar analizleri yapıldı ve 24 saatlik idrarda albümin, protein, sodyum atlımı ve kreatinin klirensi hesaplandı. Bulgular: Çalışmaya toplam 114 hasta dahil edildi. Spearman korelasyon analizinde 24 saatlik idrar sodyum atılımının vücut kitle indeksi (VKİ) ile (rho: 0,265, p: 0,004), kan üre nitrojeni ile (rho: -0,210, p: 0,025), kreatinin klirensi ile (rho: 0,313, p: 0,001), albümin ile (rho: 0,320, p: 0,001, hemoglobin ile (rho: 0,242, p: 0,013) ve trigliserid düzeyleri ile (rho: 0,261, p: 0,008) korrele olduğu görüldü. Doğrusal regresyon analizinde VKİ (B: 0,013, CI: 0.004-0,022, P: 0,004), sigara içme durumu (B: 0,132, CI: 0,02-0,243, P: 0,021), kreatinin klirensi (B: 0,002, CI: 0,001-0,004, P: 0,012)ve trigliserid düzeylerinin (B: 0,017, CI: 0,009-0,056, P: 0,003), 24 saatlik idrar sodyum atılımının bağımsız öngörücüleri olduğu bulundu. Sonuç: Çalışmamızda yeni tanı almış Tip 2 diyabetik hastalarda VKİ, kreatinin klirensi ve trigliserid düzeylerinin 24 saatlik idrar sodyum atılımı ile bağımsız olarak ilişkili oldugu saptandı.
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