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POSTTRANSPLANT DİYABETES MELLİTUS

POSTTRANSPLANT DIABETES MELLİTUS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1995

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
In this study, we investigated the prevalence, the probable risk factors and the clinical course of post transplant diabetes mellitus (PTDM). In the June of 1994, we found 15 (6 %) PTDMpa¬tients among 225 renal allograft recipients. The mean appearance time of PTDM was 3.2 ±2.8 months. Five of them were treated by diet only, 6 received oral an-tidiabetic drugs and 4 needed insulin. The fifteen PTDM patients were compared with 30 control cases randomly selected. Of the parameters investigated, only age and cumulative cyclosporin do¬se were identified as risk factors (p<0.001 and p<0.05 respectively). There was no statistically signi¬ficant difference between the two groups with regard to the following parameters age, diabetic family his¬tory; serum creatinine value and body mass index at time of the diagnosis of PTDM, the increase in body weight from the time of transplantation to the appea¬rance time of PTDM, cumulative doses of steroid. 22J±18 months after PTDM diagnosis, there was no statistically significant difference between the two groups' creatinine values (1.69±0.62 - 1.51+0.38 mgldL; 149.3+54.8 - 133.4+33.5mmollL). PTDM did not appear to have any harmful effect on graft functi¬on in short term, but increased the predisposition to the urinary tract infection.
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Abstract (Original Language): 
Bu çalışmada, merkezimizde izlenen renal allog-reft alıcılarında posttransplant diyabetes mellitus (PTDM)un prevalansı, olası risk faktörleri ve klinik seyri araştırılmıştır. Haziran 1994 'te, toplam 225 hasta arasında, 15 (% 6.6) PTDM olgusu ayırdedildi. PTDMun ortaya çıkış zamanı ortalama 3.2+2.8 ay idi. Beş hasta yal¬nızca diyabetik diyet alırken, 6 hasta oral antidiyabe-tik, 4 hasta ise insülin kullanıyordu. PTDM'lu 15 olgu ve rastgele seçilmiş 30 kontrol olgusu yaş, diyabetes mellitus soygeçmişi; PTDM saptandığı andaki kreatinin değeri, vücut kütle indek¬si; PTDM ortaya çıkana dek geçen posttransplant sü¬re içindeki ağırlık artışı, prednisolon ve siklosporinin kümülatif dozları açısından karşılaştırıldı. Bu parametrelerden yalnızca yaş ve kümülatif sik-losporin dozu PTDM için risk faktörü olarak belirlen¬di (p<0.001 ve p<0.05); diğerleri açısından iki grup arasında fark yoktu. PTDM teşhisinden ortalama 22 ± 18 ay sonra, iki grubun kreatinin değerleri arasında istatistiksel ola¬rak anlamlı bir farklılık bulunmadı; buna karşın PTDM grubunda üriner traktüs enfeksiyonu epizodu¬nun daha sık oluşu dikkat çekiciydi.
FULL TEXT (PDF): 
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  • 1
17-20
  • Turkish

REFERENCES

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