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KRONİK HEMODİYALİZ HASTALARINDA KRİYOGLOBÜLİNEMİ PREVALANSI VE HCV İNFEKSİYONU İLE İLİŞKİSİ

CRYOGLOBULINEMIA PREVALANCE AND RELATION WITH HCV INFECTION IN CHRONIC HEMODIALYSIS PATIENTS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1996

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The association between essential mixed cryoglo-bulinemia and HCV infection is well recognized. This study was designed to investigate the association bet¬ween HCV infection and cryoglobulinemia as well as its clinical and laboratory findings in chronic haemo-dialysis patients amongs whom the incidence of HCV infection is known to be high. 92 cases of end stage renalfailure on chronic hae-modialysis treatment followed in Marmara University and Başkent University Haemodialysis units were involved in the study. We studied cryoglobulin levels in 52 HCV (+) and 40 HCV(-) patients on chronic hemo-dialysis treatment Circulating cryoglobulins were fo¬und in 17 (%32.6) of the 52 HCV (+) patients and in none of the HCV (-) patients. The cryoglobulins were classified as type III in on cases and identification was not possible in the remaining 7 cases. The cryoglobu-linemia and liver function tests. ESR, IgG, IgM, and levels. Our data confirm the close link between HCV in¬fection and cryoglobulinemia and that the prevalance of circulating cryoglobulins in uremic HCV(+) pati¬ents is very close to that found in HCV related liver disease reported in literature. We plan to follow up these cases to determine prospectively the risk of de¬velopment of cryoglobulinemia syndrome.
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Abstract (Original Language): 
Esansiyel mikst kriyoglobülinemi ile HCV infeksi-yonıı arasındaki ilişki çeşitli yayınlarda vurgulanmıştır. Bu çalışma HCVinfeksiyonunun sık görüldüğü kronik hemodiyaliz programındaki olgularda kri-yoglobülinemi prevalansını, klinik bulgularını ve çe¬şitli laboratuvar parametreleriyle ilişkisini araştır¬mak amacıyla prospektif olarak yapılmıştır. Çalışmaya Marmara Üniversitesi Hemodiyaliz Ünitesi ve Başkent Üniversitesi Hemodiyaliz Ünitesi nde kronik hemodiyaliz programında olan toplam 922 olgu alınmıştır. HCV (+) 522 olgunun 17' sinde (%32.6) kriyopresipitasyon saptanırken HCV (-) 40 olgudan hiçbirinde kriyopresipitasyon saptanmamış¬tır. Kriyopresipitasyon saptanan olgulardan W unda kriyoglobülin içeriği tip III poliklonal mikst kriyoglo-bülinemi ile uyumlu bulunurken kalan yedi olguda kri-yopresipitat miktarının azlığı nedeniyle sınıflandırıl¬ması yapılamamıştır. Kriyoglobülinemik olguların hepsinin asemptomatik oldukları gözlenmiştir. Kri-yoglobülinemi ile ALT, AST, AF, GGT, TP, Albümin, IgG, IgA, IgM, Cı, CA ve ESHdüzeyleri arasında an¬lamlı bir ilişki saptanmamıştır. Sonuç olarak, çalışmamızın verileri HCV infeksi-yonu ile kriyoglobülinemi arasındaki ilişkiyi destekle¬mektedir. Kriyoglobülineminin üremik hastalardaki prevalansı literatürde bildirilen HCV ye sekonder kronik karaciğer olgularındaki prevalans ile uyumlu¬dur. Halen asemptomatik olan bu olguların kriyoglo-bülinemik sendrom gelişimi açısından prospektif izle-minin sürdürülmesi sadece bir laboratuvar bulgusu olarak saptanan kriyoglobülineminin klinikteki önemi¬ni daha iyi ortaya koyacaktır.
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  • 3
110-114
  • Turkish

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