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532 BÖBREK BİYOPSİSİNDE KRESENTIK GLOMERULONEFRIT SIKLIĞI VE KLİNİK SEYRİ

THE FREQUENCY AND CUNICAL OUTCOME OF CRESLENTIC GLOMERULONEPHRITIS AMONG 532 RENAL BIOPSIES

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1997

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
In this study, the frequency of crescentic glomerulonephritis(GN) and the clinical outcome of the patients with crescentic GN were evaluated retrospectively among 532 renal biopsies performed between January 1990 and January 1996 in our unit. Crescentic GN was determined in 23 cases(4.3%); 18 of them were primary crescentic GN( Type I in 2, Type II in 10, Type III in 6), while 5 were secondary crescentic GN. Sixteen of 23 patients whose mean creatinin levels were 7.9±4.2 mg/dl (1.5-16.6) at the first admission, dialysis requirement occurred during hospitalization period. Pulse steroid was applied in 16 patients, pulse steroid and oral cyclophosphamide in 4, pulse steroid and plasmapheresis in 2, plasmapheresis and pulse cyclophosphamide in 1. In 10 cases(43%), initial response to the therapy was obtained, but end-stage renal disease developed in 6 of them in 1 year despite initial good response. Creatinine levels at the first examination and the percentage of crescent in the biopsies were significantly higher in the patients who do not show response to the therapy than those of the patients with initial response. At the end of follow-up period of mean 32±14 months, 17 of 20 surviving patients were on renal replacement therapy(14 on dialysis, 3 on renal transplantation), 3 had stable renal function.
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Abstract (Original Language): 
Bu çalışmada, Ocak 1990 - Ocak 1996 arasında merkezimizde yapılmış 532 böbrek biyopsisi içinde, kresentik glomerülonefrit (GN) sıklığı ve bu olguların klinik seyirleri retrospektif olarak değerlendirildi. Toplam 23 olguda(% 4.3) kresentik GN saptandı; bunların 5' i sekonder iken, 18' i primer kresentik GN idi (2'si Tip 1, 10' u Tip 2, 6'sı Tip 3). ilk başvurularında ortalama kreatinin değeri 7.9±4.2 mg/dl (1.5¬16.6) olan 23 olgunun, 16' sında yatışları süresinde diyaliz gereksinimi ortaya çıktı. Hastaların 16' sına pulse steroid, 4' üne pulse steroid ve oral siklofosfamid, 2' sine plazmaferez ve pulse steroid, V ine plazmaferez ve pulse siklofosfamid uygulandı. Ol¬guların 10' unda (% 43) tedaviye başlangıçta iyi ya¬nıt alındı. Tedaviye yanıt vermeyen olguların baş¬langıçtaki kreatinin değeri ve biyopsideki kresent yüz¬desi, başlangıçta yanıt göster enler inkinden belirgin olarak daha yüksekti. Ortalama 32±14 aylık izlem sü¬resi sonunda, yaşayan 20 hastanın 17' si renal replasman tedavisi almaktaydı(14' ü diyaliz, 3' U renal transplantasyon), 3' U ise stabil renal fonksiyonlarla poliklinik izlemindeydi.
FULL TEXT (PDF): 
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  • 1-2
31-33
  • Turkish

REFERENCES

References: 

1. Glassock RJ, Adler SG, Ward HJ, Cohen AH: Primary glomerular diseases. In Brenner BM, and Rector FC(eds): The Kidney, 4th ed. W.B. Saunders, Philadelphia, 1993; p:1193.
2. Whitworth JA, Morel-Moroger L, Mignon F, Richet G. The significance of extracapillary proliferation. Clinicopathological review of 60 patients. Nephron 1976;
16: 1-19.
3. Couser WG. Rapidly progressive glomerulonephritis: Classification, pathogenetic mechanism and therapy. Am
J Kidney Dis 1988; 11: 449-464.
4. Cohen AH, Border WA, Shankel E, Glassock RJ.
Crescentic glomerulonephritis: Immune or nonimmune pathogenesis. Am J Nephrol 1981; 1: 78-83.
5. Bolton WK, Couser WG: Intravenous pulse methylprednisolone therapy of acute crescentic rapidly progressively glomerulonephritis. Am J Med 1979; 66: 495-502.
6. Lockwood CM, Pearson TA, Rees N, et al: Immunosuppressive and plasma exchange in the treatment of Goodpasture's syndrome. Lancet 1976: 1: 711-5.
7. Atkins RC, Thomson NM: Rapidly progressive glomerulonephritis. In Schrier RW, Gottschalk CW (eds): Diseases of The Kidney. 5th ed., Little Brown and
Company, Boston 1994; p: 1701.
8. Neild GH, Cameron JS, Ogg CS, Turner DR, Williams
DG, Brown CB, Chantler C, Hicks J: Rapidly progressive glomerulonephritis with extensive glomerular crescent formation. Q J Med 1983; 52; 395-416.
9. Bruns FJ, Adler S, Fraley DS, Segel DP. Long-term follow-up of aggressively treated idiopathic rapidly progressive glomerulonephritis. Am J Med 1989; 86: 400¬406.

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