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KRONİK HEMODİYALİZ HASTALARINDA İŞİTME KAYBI VE ANTİOKSİDANLAR

HEARING LOSS AND ANTIOXIDANTS IN CHRONIC HEMODIALYSIS PATIENTS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1998

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
No satisfactory explanation has been made about chronic hemodialysis-induced hearing loss, yet. This study has been aimed to investigate whether there is a possible role of changes in antioxidant defense mechanisms in chronic hemodialysis-induced hearing loss. Sixty-six patients with chronic renal failure and 22 healthy volunteers were included in the study. The patients were divided into two groups as group 1 and 2 on the basis of the presence and absence of hearing loss, respectively. Forty-seven of 66 patients had hearing loss and nine-ten had not hearing loss. The controls were admitted as group 3. In all patients and controls audiologic tests were performed and the activities of antioxidants, and blood urea nitrogen, creatinin, uric acid, and albumin, and hearing threshold values were determined. This study showed that decreasing in antioxidant enzymes activities in chronic hemodialysis patients might have an important role in hearing loss.
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Abstract (Original Language): 
Kronik hemodiyalizin yol açtığı işitme kaybının etyolojisi konusunda henüz net bir sonuca ulaşılamamıştır. Bununla beraber, etyopatogenezde antioksidan savunma mekanizmalarındaki yetersizlik en popüler olarak suçlanan faktörlerdendir. Çalışmamız, antioksidan savunma mekanizmaları ile kronik hemodiyaliz (KHD) hastalarında ortaya çıkan işitme kaybı arasındaki ilişkiyi araştırma amacıyla yapıldı. Çalışmamıza KHD uygulanan 66 hasta ve kronik böbrek yetmezliği ve işitme kaybı şikayeti olmayan sağlıklı 22gönüllü dahil edildi. KHD uygulanan 66hastanın işitme kaybı saptanan 47'si Grup I'i ve işitme kaybı saptanmayan 19'u Grup 2 'yi oluştururken, 22 sağlıklı gönüllü Grup 3 'ü (kontrol grubu) oluşturdu. Çalışmamıza dahil edilenlerin tümünün odyolojik testleri, antioksidan enzimler (bakır-çinko süperoksit dizmutaz, katalaz ve glutatyon peroksidaz), kan üre azotu (BUN), kreatinin, ürik asit, hemoglobin ve albümin seviyeleri ölçüldü. Sonuç olarak, KHD hastalarında işitme kaybının antioksidan enzim aktivitelerindeki yetersizlikle ilişkili olabileceği kanısına varıldı
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  • 2
97-101
  • Turkish

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