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SÎSTEMÎK LUPUS ERÎTEMATOZUS OLARAK TEDAVİ BAŞLANAN BÎR TROMBOTÎK TROMBOSÎTEMÎK PURPURA (TTP) HASTASI

A PATIENT WITH THROMBOTIC THROMBOCYTOPENIC PURPURA TREATED AS A SYSTEMIC LUPUS ERYTHEMATOSUS INITIALLY

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Abstract (2. Language): 
Thrombotic thrombocytopenic purpura (TTP) is a rare, life threatened disease. It is characterized by fever, variable neurological manifestations, progressive renal failure, microangiopathic hemolytic anemia and thrombocytopenia. TTP may be associated with some autoimmune diseases such as systemic lupus erythematosus (SLE). TTP may be confused with SLE because its classical sympoms such as fever, neurological manifestations, renal failure, thrombocytopenia can be seen in SLE. We report here a patient with TTP, confused with SLE, and whom the diagnosis of TTP was supported by autopsi.
Abstract (Original Language): 
Trombotik trombositopenik purpura (TTP) nadir görülen hayatı tehdit eden bir hastalıktır. Ateş, dalgalanmalar gösteren nörolojik bozukluklar, progresif renal yetmezlik, mikroanjiopatik hemolitik anemi, trombositopeni ile karekterizedir (1). TTP, Sistemik Lupus Eritematozus (SLE) gibi otoimmun hastalıklarla birlikte olabilir. TTP 'nin klasik semptomları olan ateş, nörolojik bozukluklar, renal, bozukluklar ve trombositopeninin SLE 'de de görülmesi nedeniyle, SLE ile karışabilir. Bu olgu sunumunda ilk etapta SLE tanısı almış fakat TTP'nin klasikpentadının görülmesi ile TTP tanısı konulmuş, hasta multipl organ disfonksiyon sendromu (MODS) nedeni ile kaybedilmiş, tanısı otopsi ile desteklenmiş bir hasta tartışılacaktır.
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REFERENCES

References: 

1. Ridollfi RL, Bell WR: Thrombotic thrombositopenic purpura. Report of25 cases and review ofthe literature. Medicine 60: 413, 1981
2. Byrnes JJ, Moake JL: Thrombotic thrombositopenic purpura and the haemolytic- uremic syndrome: Evolving consept of pathogenesis and therapy. Clin
Haemetol 15:413, 1986
3. Amorosi E.L. & Ultman, J.E: TTP. Report of 16 cases and review of literature. Medicine, 45, 139-157, 1966.
4. Neame PD: Immunologic and other factors in thrombotic thrombositopenic purpura(TTP). Semin
Thromb Hemost 6: 416, 1980
5. Lian EC-Y, Harkness DR, Byreness JJ, Wallach H,
Numez R: Presence of a platelet aggregation factor in the plasma of the patients with thrombotic rthrombositopenic purpura (TTP) and its inhibition by normal plasma. Blood 53: 333, 1979.
6. Siddiqui FA, Lian EC-Y: Novel platelet- aglglutinating protein from a thrombotic thrombositopenic purpura
plasma. J Clin Invest 76: 1330, 1985
7. Remuzzi G, Misiani R, Mecca G: Thrombotic thrombositopenic purpura. A deficiancy plasma factors regulating platelet vessel wall interaction. N Engl .1 Med 299:311, 1978
8. Moake JL, Rudy CK, Troll JH, et al: Unusual large
plasma factor VIII: von Willebrand factor multimers in chronic relapsing thrombotic thrombositopenic
purpura. N Engl J Med 307: 1432, 1982
9. Takahashi H, Tatewaki W, Nakamura T, Hanano M, Wada K, Shibata A: Coagulation studies thrombotic thrombositopenic purpura with special reference to von willebrand factor and protein S. Am J Hematol 30:14,
1989
10. Török et al: Increasing mortality from thrombotic thrombositopenic purpura in the United States-Analysis of national mortality data, 1968- 1991. Am J
Hematol 50: 84-90, 1995
11. Nesher G, Hanna VE, Moore TL, Hersh M, Osborn TG: Thrombotic microanjiopathic hemolytic anemia and sistemic lupus eriythematosus. Semin Artritis Rheum
24: 165, 1994

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