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MÎKROALBUMÎNÜRÎ ESANSÎYEL HİPERTANSİYONDA SİSTEMİK VE RENAL ENDOTEL ETKİLENME GÖSTERGESİ MİDİR?

IS MICROALBUMINURIA A MARKER OF SYSTEMIC AND RENAL ENDOTHELIAL DEMAGE IN ESSENTIAL HYPERTENSION?

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1999

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Study was performed on 168 patients with essential hypertension (HT). Their SBP, DBP were 161,4±16 and 100,8±8 mmHg. Mean age was 47,6±9 years and HT duration was 46,8±4 months. 88 healthy subjects with mean age 46,4±9 years were included as a control. Endogenous creatinine clearance (GFR), proteinuria, urinary albumin excretion in minute (UAE) were measured. Plasma fibrinogen, vonWillebrand factor (vWF), serum lipoprotein, uric acid, electrolytes were measured. Proteinuria (P:0,019), UAE (P:0,000), fibrinogen (P:0,003), vWF (P:0,012), triglyceride (P: 0,001) and uric acid (P:0,000) values were higher in HT group. Microalbuminuria (MA) was observed %3,4 in control and %32 in HT group. There was %65 hypertensive retinopathy in patients. Our observations suggest that HT effects the systemic and renal endothelium at early stage.
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Abstract (Original Language): 
Esansiyel hipertansiyon (HT) tanısı konan, SKB:161,4±16mmHg, DKB: 100,8±8mmHg, yaş ortalaması 47,6±9 yıl, HT yaşı 46,8±4 ay olan non- komplike 168 olgu ve SKB:120,2±7mmHg, DKB: 79,3±5mmHg olan 88 sağlıklı birey ile çalışıldı. Endojen kreatinin klirensi (GFR), proteinüri, dakika idrarla atılan albumin (UAE) değeri hesaplandı. Sistemik vasküler endotel göstergeleri olan plazma fibrinojen ve vonWillebrand Faktör (vWF) ölçüldü. Serumda lipoproteinler, ürik asid, elektrolitler ölçüldü. HT lu grupta proteinüri (P:0,019), UAE (P:0,000), fibrinojen (P: 0,003), vWF (P: 0,012), trigliserid (P:0.001) ve ürik asid (P:0.0000) yüksek bulundu. Kontrol grubunda %3,4 ve HT grubunda %32 oranında mikroalbuminüri (MA) bulundu. HT grubun %65 nde retinopati bulundu. Bulgularımız HT un erken evrede hedef organları etkileyebildiğini göstermektedir.
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  • 2
74-78
  • Turkish

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