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ERİTROSİT MEMBRAN SERTLİĞİ (VEYA) ERİTROSİT DEFORMABİLİTESİ; PROTEİNÜRİK HASTALARDA KAN VE PLAZMA VİSKOZİTELERİ

ERYTHROCYTE MEMBRANE STIFFNESS (OR) RED CELL DEFORMABILITY, BLOOD AND PLASMA VISCOSITY IN PROTEINURIC PATIENTS

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Abstract (2. Language): 
In recent years, anemia in nephrotic syndrome has been the subject of investigation. In addition to erythropoietin deficiency the anemia of proteinuric patients is tried to be explained by a shortened erythrocyte lifespan due to decreased red deformability. Twelve proteinuric patients were compared with two age and sex-matched control groups (anemic and healthy). Red cell deformability and viscosities at three different shear rates were evaluated. It is demonstrated that in proteinuric patients red cell deformability and blood viscosities at different shear rates were decreased.
Abstract (Original Language): 
Son yıllarda nefrotik sendromlu hastalardaki anemi irdelenmeye başlanmıştır. Erythropoietin eksikliği dışında proteinürik hastalardaki anemi eritrosit deformabilitesi bozulması nedeniyle kısalmış eritrosit yaşam süresi ile açıklanmaya çalışılmıştır. On iki proteinürik hasta yaş ve cins ile uyumlu iki kontrol grubu ile karşüaştırılmıştır (anemik ve sağlıklı). Eritrosit deformabilitesi ve değişik kayma hızlarında kan ve plazma viskoziteleri değerlendirildi. Hafif ve orta dereceli renal yetersizlikte proteinürinin tek başına eritrosit deformabilitesini ve değişik kayma hızlarında kan vizkositelerini azalttığı gösterilmiştir
FULL TEXT (PDF): 
206-212

REFERENCES

References: 

1. Viljoen M, Oliveira de AA, Milne FJ .Physical
properties of the red cells in chronic renal
failure.Nephron, 1991, 59:271-278
2. Shibasaki T, Misawa T, Matsinnoto H, Abe S, Nakano H, Matsuda H, Gomi H, Ohno I, Ishimoto F, Sakai 0. Characteristics of anemia in patients with nephrotic syndrome. Nippon Jinzo Gakkai Shi,1994, 36(8):896-
901
3. Ishimitsu T, Ono H, Sugiyama M, Asakawa H, Oka K, Numabe A, Abe M, Matsuoka H. Yagi S. Successful erythropoietin treatment for severe anemia in nephrotic syndrome without renal dysfunction. Nephron, 1996, 74(3):607-10
4. Matrai A, Wittingham RB and Ernst E. A simple method of estimating whole blood viscosity at standardized hematocrit. Clin Hemorheol 1987, 7:261¬265
5. Mokken FCh., Kedaria M., Ilenny ChP, Hardeman MR, and Gelb AW The clinical importance of erythrocyte deformability, a hemorheological parameter. Rev Art. in AnnHematol, 1992,64: 113-122
6. Lowe GDO, Evaluation of rheological therapy by orally administred drugs.,Clin Hemorrheol, 1984, 1: 513-526
7. Mohandas N., Philips WM, bessis M Red blood cell
211
detormability and hemolytic anemias. Semin Hematol ,
1979, 16:95-114
8. Stuart J, Erythrocyte rheology, J Clin Pathol, 1985, 38: 965-977
9. Weed RI, The importance of erythrocyte detormability.
Am J Med, 1970, 49: 147-151
10. Weed RI, LaCelle PL, Merrill EW. Metabolic
dependence of red cell detormability. J Clin Invest
48:795-809
11. Emerson CP, Burrows BA: The mechanism of anemia and its influence on renal function in chronic uremia
(abstract). J Clin Invest, 1949, 28: 779
12. Desforges JF, Dawson JP. The anemia of renal failure. Arch Intern Med 1958, 101:326-332
13. Yawata Y, Howe R, Jacob HS: Abnormal red cell metabolism causing hemolysis in uremia. A defect potentiated by tap water hemodialysis.Ann Intern Med,
1973,79:362-367
14. Hartley LC, Morgan TO, Innis MD, et al: Splenectomy for anemia in patients on regular haemodialysis. Lancet,
1971,2:1343-1345
15. Forman S, Bischel M, Hochstein P: Erythrocyte deformability in uremic hemodialysed patients. Ann
Intern Med, 1973,79:841-843
16. Sirs JA : Chapter 2: Erythrocyte flexibility and whole blood viscosity in Clinical aspects of blood viscosity and cell deformability edited by GDO Lowe, JC Barbenel and CD Forbes (Berlin:Springer-Verlag), 1981, pp 9-18
17. Amin TM, Sirs JA and Turner P:Measurement of erythrocyte deformability using a stroboscopic recording
centrifuge. Phys Med Biol, 1983, 28(3):269-275
18. Lowe GDO:Red cell deformability-Metods and Technology: Clin Hemorrheol, 1981,1:513-526
19. Sirs JA: Measurement of erythrocyte deformability with
the single sample method, Phys Med Biol, 1970, 15:9-14
20. Vaziri ND, Kaupke CJ, Barton CH, Gonzales E. Plasma concentration and urinary excretion of erythropoietin in
adult nephrotic syndrome.Am J Med, 1992, 92:35-40
21. Bayes B, Serra A, Junca J and Lauzurica R. Successful treatment of anemia of nephrotic syndrome with recombinant human erythropoietin. Letter Nephrol Dial Transpl,1998, 13(7): 1888
22. Dormandy JA. Red cell deformability. Eur Neurol, 1983,
22 [Suppl 1]: 23-29
23. Machiedo GW, Powell RJ, Rush BF, Swislock NI,
Dikdan G. The incidence of decreased red blood cell deformability in sepsis and the association with oxygen free radicals damage and multiple-system organ failure.
Arch Surg, 1989, 124:1386-1388
212

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