You are here

Home » Content

ROMATOID ARTRÎTLÎ BÎR HASTADA MULTIPLE MYELOMA YA BAĞLI AKUT BÖBREK YETMEZLİĞİ

ACUTE RENAL FAILURE DUE TO MULTIPLE MYELOMA IN A PATIENT WITH RHEUMATOID ARTHRITIS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Increase in the relative risk of development of secondary malignancy in patients with rheumatoid arthritis (RA) have been demonstrated, possibly either due to underlying immunological disorders, or to cytotoxic drugs used for therapy. In addition, RA itself and drugs may cause numerous renal and pulmonary disorders. Here, we describe a 52-year-old-woman with a 15-year history ofRA who developed acute renal failure due to multiple myeloma. She also had severe pulmonary fibrosis as a complication of RA. Our findings suggest that renal involvement due to multiple myeloma should be kept in mind in differential diagnosis of renal dysfunction in patients with RA.
Bookmark/Search this post with
Abstract (Original Language): 
Romatoid artrit (RA) seyrinde gerek hastalığın altında yatan immünolojik bozukluklar gerekse de tedavide kullanılan sitotoksik ilaçların etkisi ile sekonder malignensi gelişim riski artmıştır. Ayrıca bu hastalarda, hastalığın kendine ve ilaçlara bağlı olarak çeşitli renal ve pulmoner bozukluklar gelişebilmektedir. Burada, 15 yıldır romatoid artriti olan ve multiple myelomaya bağlı akut böbrek yetmezliği gelişen 52 yaşında bir bayan hasta sunulmaktadır. Hastada ayrıca RA 'in pulmoner komplikasyonu olarak şiddetli pulmoner fıbrozis mevcuttu. Bulgularımız, RA li hastalarda renal disfonksiyonun ayırıcı tanısında multiple myelomaya bağlı renal tutulumun da düşünülmesi gerektiğini göstermektedir.
FULL TEXT (PDF): 
PDF icon pdf_tndt_300.pdf
  • 2
118-121
  • Turkish

REFERENCES

References: 

1. Lipsky PE. Rheumatoid arthritis. In: Anthony SF, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL (eds), Harrison's principles of internal medicine. McGraw-Hill, New York 1998, pp 1880-1888.
2.
Yaşa
r Karaaslan, Tekin Akpolat. Sistemik hastalıklarda böbrek tutulumu. In: Tekin Akpolat, Cengiz Utaş, Gültekin Süleymanlar (eds), Nefroloji El Kitabı. (2.baskı) Güzel Sanatlar Matbaası A.Ş, istanbul, 1999, ss 206-216
3. Youinou P, Le Corre R, Dueymes M. Autoimmune diseases and monoclonal gammopathies. Clin Exp
Rheumatol 1996;14 Suppl 14:S55-8)
4. Eriksson M. Rheumatoid arthritis as a risk factor for multiple myeloma: a case-control study. Eur J Cancer 1993; 29(2):259-63
5.
Dile
k K. Akut böbrek yetmezliği. In: Akpolat T, Utaş C, Süleymanlar G (eds), Nefroloji El Kitabı (2.baskı) Güzel Sanatlar Matbaası A.Ş, istanbul, 1999, ss 206¬216
6. Kelly CA. Paraproteins in rheumatoid arthritis and related disorders. Int J Clin Lab Res 1992; 21(4):289-91 (abstract)
7. Cohen HJ, Bernstein RJ, Grufferman S. Role of immune stimulation in the etiology of multiple myeloma: A case-control study. Am J Hematol 1987; 24:119.
8. Akira S, Kishimoto T. The evidence for interleukin-6 as an autocrine growth factor in malignancy. Semin
Cancer Biol 1992; 3(1): 17-26
9. Oymak O. Toksik Nefropati. In: Akpolat T, Utaş C, Süleymanlar G (eds), Nefroloji El Kitabı (2.baskı ). Güzel Sanatlar Matbaası A.Ş, istanbul 1999, ss 372-381
10. Chevrel G, Berger F, Miossec P et al. Hodgkin disease and B cell lymphoproliferation in rheumatoid arthritis patients treated with methotrexate: a kinetic study of lymph node changes. Arthritis Rheum 1999; 42: 1773¬1776.
11. Georgescu L, Paget SA. Lymphoma in patients with rheumatoid arthritis: what is the evidence of a link with
low methotrexate? Drug Safety 1999, 20: 475-487.
12. Penn I. Cancers complicating organ transplantation. N
EngJMed, 1991; 323, 1767-9.
120
13. Ganeval D, Cathomen M, Noel LH, Grunfeld JP. 15. Pirani CL, Silva F, D'Agati V, Chander P, Striker LM. Kidney involvement in multiple myeloma and related Renal lesions in plasma cell dyscrasias: ultrastructural disorders. Contrib Nephrol 1982; 33: 210-222 observations. Am J Kidney Dis 1987; 10(3): 208-221
14. Winearls CG. Acute myeloma kidney. Kidney Int 1995; 48(4): 1347-1361
121

Thank you for copying data from http://www.arastirmax.com