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Çocuklukta idyopatik nefrotik sendrom ve tedavi yöntemleri

Idiopathic nephrotic syndrom of the childhood and its treatment

Journal Name:

  • Türkiye Aile Hekimliği Dergisi

Publication Year:

  • 2009
DOI: 
doi:10.2399/tahd.09.064

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Idiopathic nephrotic syndrome is a chronic glomerular disorder seen in childhood. The first objective in the management of this disorder is to induce remission to resolve proteinuria and edema. In these cases the most common cause is minimal change disease (MCD). The majority of patients respond to corticosteroid therapy. Steroid sensitive nephrotic syndrome usually has good prognosis and 80% of cases go into remission by puberty. The frequently relapsing nephrotic syndrome requires other treatment options. The purpose of these treatments is to induce remission and to pro¬ vide steroid sparing effect. These agents include cancer agents like cyclophosphamide, transplant medication like cyclosporin, and immunomodulators like levamisole. The success with these med¬ ications is variable and their side effect profiles are unique.
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Abstract (Original Language): 
Çocuklukta görülen idyopatik nefrotik sendrom kronik glomerüler bir hastalıktır. Bu hastalığın tedavisinde öncelik, hastalığı remisyona sokarak proteinüri ve ödemin ortadan kalkmasını sağlamaktır. Vakaların çoğunda ana neden minimal lezyon hastalığıdır (MLH). Hastaların büyük çoğunluğu kortikosteroide cevap verir. Steroide hassas nefrotik sendrom genellikle prognozu iyi olan bir hastalıktır; vakaların %80'i ergenlik çağına yaklaştıkça kendiliğin¬ den düzelir. Hastalığın sık tekrarlayan tiplerinde steroidlerin yan etkilerinden korunmak için steroid dışı tedaviler de gerekir. Bu amaçla kemoterapötik siklofosfamid, bağışıklık baskılayıcı siklosporin ve bir immünomodülatör olan levamizol kullanılır. Başarı oranları değişken olan bu ilaçların da kendilerine özgü yan etkile¬ ri vardır.
FULL TEXT (PDF): 
PDF icon arastrmx_116859_13_pp_64-67.pdf
  • 2
64-67
  • Turkish

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