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Doğumsal hipotiroidinin nedenini belirlemede güvenilir bir parametre: Serum tiroglobulin düzeyi

Serum thyroglobulin levels: a reliable parameter in determining the etiology of congenital hypothroidism

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DOI: 
doi:10.2399/tahd.09.127

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Abstract (2. Language): 
Objective: Hypothyrodism is one of the most widespread preventable causes of mental retardation. Thyroglobulin level gives important clues to determine the etiology of and fix the therapy plan for hypothroidism. This study aims to determine the role of and significance of serum thyroglobulin levels in the etiology of hypothyroidism. Methods: The medical records of 265 cases of hypothyroidism (123 female, 142 male) in the endocrinology department, were evaluated retrospectively. Results: Serum thyroglobulin levels were measured in agenesis, hypoplasia, ectopia and dyshormonogenesis as 3.07 ng/ml, 40.92 ng/ml, 33.1 ng/ml, 499 ng/ml and 52.25 ng/ml for disorders in which the etiology could not be determined, respectively. Conclusions: In congenital hypothyroidism the etiology aids to determine the duration of the therapy and to estimate prognosis. The serum thyroglobulin level is a reliable parameter to determine the etiology
Abstract (Original Language): 
Amaç: Doğumsal hipotiroidi, zeka geriliğinin en yaygın önlenebilir nedenlerinden biridir. Hastalığın etiyolojisinin belirlenmesi, tedavinin planlanıp sürdürülmesine yol gösterir. Bu çalışmada serum tiroglobulin (Tg) düzeyinin nedeni belirlemedeki yeri ve önemi araştırılmıştır. Yöntem: Endokrinoloji polikliniğinde nedeni belirlenmiş 265 hipotiroidi olgusunun (123 kız, 142 erkek) kayıtları retrospektif ola¬ rak değerlendirildi. Bulgular: Serum Tg değerleri bezin yokluğu, az gelişmesi, farklı yerde olması ve hormon yapımı bozukluğunda sırasıyla 3.07 ng/ml, 40.92 ng/ml, 33.1 ng/ml ve 499 ng/ml, nedeni belirlenemyen diğer tanılarda ise 52.25 ng/ml idi. Sonuç: Doğumsal hipotiroidide tedavi süresini ve seyri öngörebil¬ mek için neden belirlenmelidir. Serum tiroglobulin düzeyi nedeni belirlemede güvenilir bir parametredir

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