You are here

Amalgam dolguların insan dokuları üzerindeki etkileri

Effects of amalgam fillings on human tissues

Journal Name:

Publication Year:

Keywords (Original Language):

Abstract (2. Language): 
Dental amalgam is one of the main sources of exposure to mercury in industrialised countries. A suspected link exists between low doses of mercury derived from dental amalgam and neurodegenerative or neurobehavioural disorders. Mercury is both neurotoxic and nephrotoxic at high doses. Many countries, such Swe¬den, recommend that the use of amalgam should be restricted, particularly in pregnant women and children. As part of a global strategy to eliminate mercury, the European Parliament has asked the Commission to draft legislation limiting the use of dental amalgam. This article review the effects of amalgam of human tis¬sues in the light of the current literature.
Abstract (Original Language): 
Amalgam, sanayileşmi ş ülkelerde cıvaya maruz kalmanın en önemli sebeplerinden biridir. Amalgam dolgulardan salınan düşük dozdaki cıva ile nörodejeneratif veya nörodavranışsal bozukluklar arasında bir bağlantı olduğu düşünülmektedir. Yüksek dozda alınan cıva hem nörotoksik ve hem de nefrotoksik etkiye sahiptir. isveç gibi bazı ülkeler, hamile kadınlarda ve çocuklarda amalgam kullanımını sınırlandırmıştır. Avrupa Parlamentosu, küresel bir stratejinin parçası ola¬rak, cıvanın zararlı etkilerini ortadan kaldırmak için, amalgam kulla¬nımını sınırlayan bir yasa tasarısı hazırlamıştır. Bu makale amalgamın insan dokularına etkilerini güncel literatür ışığında gözden geçir¬mektedir.
83-86

REFERENCES

References: 

1. Brownawell AM, Berent S, Brent RL, ve ark. The potential adverse health effects of dental amalgam. Toxicol Rev 2005;24:1-10.
2. Barregard J, Svalander C, Schutz A, ve ark. Cadmium, mercury, and lead in kidney cortex of the general Swedish population: a study of biopsies from living kidney donors. Environ Health Perspect 1999;107:867-71.
3. Gottwald B, Traencker I, Kupfer J, ve ark. "Amalgam disease" - poisoning, allergy, or psychic disorder? Int J Hyg Environ Health 2001;204:223-9.
4. Guzzi G, Grandi M, Cattaneo C. Should amalgam fillings be removed?
Lancet 2002;360:2081.
5. Becker K, Schulz C, Kaus S, Seiwert M, Seifert B. German Environmental Survey 1998 (GerES III): Environmental pollutants in the urine of the German population. Int J Hyg Environ Health 2003;206:15-24.
6. Kingman A, Albertini T, Brown LJ. Mercury concentrations in urine and whole blood associated with amalgam exposure in a US military popula¬tion. J Dent Res1998;77:461-71.
7. Nylander M, Weiner J. Mercury and selenium concentrations and their interrelations in organs from dental staff and the general population. Br J
Ind Med 1991;48:729-34.
8. Zimmer H, Ludwig H, Bader M. Determination of mercury in blood, urine and saliva for the biological monitoring of an exposure from amal¬gam fillings in a group with self-reported adverse health effects. Int J Hyg
Environ Health 2002;205:205-11.
9. Galic N, Prpic-Mehicic G, Prester LJ, Blanusa M, Krnic Z, Ferencic Z. Dental amalgam mercury exposure in rats. Biometals1999;12:227-37.
10. Galic N, Prpic-Mehicic G, Prester LB, Krnic Z, Blanusa M, Erceg D. Elimination of mercury from amalgam in rats. J Trace Elem Med Biol
2001;15:1-4.
11. Leistevuo J, Leistevuo T, Helenius H, ve ark. Dental amalgam fillings and the amount of organic mercury in human saliva. Caries Res2001;35:163-6.
12. Leong CCW, Syed NI, Lorscheider FL. Retrograde degeneration of neu-rite membrane structural integrity of nerve growth cones following in vitro exposure to mercury. Neuro Report 2001;12:733-7.
13. Pendergrass JC, Haley BE. Inhibition of brain tubulin-guanosine 5'-triphosphate interactions by mercury: similarity to observations in Alzheimer's diseased brain. MetalIons on Biological systems'de. Ed: Sigel
A, Sigel H. New York, Dekker; 1997:461-78.
14. Guzzi G, Grandi M, Cattaneo C, ve ark. Dental amalgam and mercury levels in autopsy tissues: food for thought. Am J Forensic Med Pathol 2006;
27:42-5.
15. Drasch G, Schupp I, Riedl G, Günther G. Einfufi von Amalgamfüllungen auf die Quecksilberkonzentration in menschlichen Organen. Dtsch Zahnarztl Z 1992;47:490-6.
16. Ehmann WD, Markesbery WR, Alauddin M, Hossain TIM, Brubakern EH. Brain trace elements in Alzheimer's disease. Neurotoxicology 1986;7:
197-206.
17. Ahlrot-Westerlund B. Mercury in cerebrospinal fluid in multiple sclero¬sis. Swed J Biol Med 1989;1:6-7.
18. Siblerud RL. A comparison of mental health of multiple sclerosis patients with silver/mercury dental fillings and those with fillings removed. Psychol
Rep1992;70:1139-51.
19. Huggins HA, Levy TE. Cerebrospinal fluid protein changes in multiple clerosis after dental amalgam removal. Altern Med Rev 1998;4:295-300.
20. Fung YK, Meade AG, Rack EP, Blotcky AJ. Brain mercury in neurode-generative disorders. J Toxicol Clin Toxicol 1997;35:49-54.
21. Weidinger S, Kramer U, Dunemann L, Mohrenschlager M, Ring J, Behrendt H. Body burden of mercury is associated with acute atopic eczema and total IgE in children from southern Germany. J Allergy Clin
Immunol2004;114:457-9.
22. Berlin M. Mercury in dental-filling materials - an updated risk analysis in environmental medical terms. The Dental Material Comission - Care and Consideration Sweden; 2003.
23. Guttman-Yassky E, Weltfriend S, Bergman R. Resolution of orofacial granulomatosis with amalgam removal. J Eur Acad Dermatol Venerol 2003;
17:344-7.
24. Bartova J, Prochazkova J, Kratka Z, Benetkova K, Venclikova Z, Sterzl I. Dental amalgam as one of the risk factors in autoimmune diseases. Neuro
Endocrinol Lett 2003;24:65-7.
25. Rampersad GC, Suck G, Sakac D, ve ark. Chemical compounds that tar¬get thiol-disulfide groups on mononuclear phagocytes inhibit immune mediated phagocytosis of red blood cells. Transfusion 2005;45:384-93.
26. Wong L, Freeman S. Oral lichenid lesions (OLL) and mercury in amal¬gam fillings. Contact Dermatitis 2003;48:74-9.
27. Guttman-Yassky E, Weltfriend S, Bergman R. Resolution of orofacial granulomatosis with amalgam removal. J Eur Acad Dermatol Venerol2003;
17:344-7.
28. Bartram F, Donate HP, Müller KE, ve ark. Significance of the patch test and the lymphocyte transformation test in the diagnostic of type IV-sen-
sitazion. J Lab Med2006;30:101-6.
29. Venclfkovâ Z, Benada O, Bârtovâ J, ve ark. In vivo effects of dental cast¬ing alloys. Neuro Endocrinol Lett 2006;27:61-8.
30. Wortberg W. Intrauterine Fruchtschadigung durch Schwermetallbelastung der Mutter. Umwelt Medizin Gesellschaft 2006;19:274-80.
31. Houston MC. The role of mercury and cadmium heavy metals in vascu¬lar disease, hypertension, coronary heart disease, and myocardial infarc¬tion. Altern Ther Health Med2007;13:128-33.
32. Frustaci A, Magnavita N, Chimenti C, Cladarulo M, Sabbioni E, Pietra R. Marked elevation of myocardial trace elements in idiopathic dilated cardiomyopathy compared with secondary cardiac dysfunction. J Am Coll
Cardiol1999;33:1578-83.
Türkiye Aile Hekimliği Dergisi |
Turkish Journal of Family Practice | Cilt 16 | Sayı 2 | 2012
85
33. Dodes JE. The amalgam controversy. An evidence-based analysis. J Am
Dent Assoc2001;132:348-56.
34. Boyd ND, Benediktsson H, Vimy MJ, Hooper DE, Lorscheider FL. Mercury from dental "silver" tooth fillings impairs sheep kidney function.
Am J Physiol1991;261:1010-4.
35. Mortada WI, Sobh MA, El-Defrawy MM, Farahat SE. Mercury in den¬tal restoration: is there a risk of nephrotoxicity? J Nephrol2002;15:171-6.
36. Trachtenberg F, Barregârd L. The effect of age, sex, and race on urinary markers of kidney damage in children. Am J Kidney Dis 2007;50:938-45.
37. Gorell JM, Rybicki BA, Johnson C, Peterson EL. Occupational metal exposures and the risk of Parkinson's disease. Neuroepidemiology1999;18:
303-8.
38. Miller K, Ochudto S, Opala G, Smolicha W, Siuda J. Parkinsonism in chronic occupational metallic mercury intoxication. Neurol Neurochir Pol
2003;37:31-8.
39. Dantzig PI. Parkinson's disease, macular degeneration and cutaneous signs of mercury toxicity. J Occup Environ Med 2006;48:656.
40. Harakeh S, Sabra N, Kassak K, Doughan B, Sukhn C. Mercury and arsenic levels among Lebanese dentists: a call for action. Bull Environ Contam Toxicol 2003;70:629-35.
41. Tezel H, Ertas OS, Ozata F, Erakin C, Kayali A. Blood mercury levels of dental students and dentists at a dental school. Br Dent J2001;191:449-52.
42. Lindbohm ML, Ylöstalo P, Sallmen M: Occupational exposure in den¬tistry and miscarriage. Occup Environ Med 2007;64:127-33.
43. Jones L, Bunnell J, Stillman J. A 30-year follow-up of residual effects on New Zealand School Dental Nurses, from occupational mercury expo¬sure. Hum Exp Toxicol 2007;26:367-74.
44. Echeverria D, Woods JS, Heyer NJ, ve ark. The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humans. Neurotoxicol Teratol
2006;28:39-48.
45. Rowland A, Baird D, Weinberg C, Shore D, Shy C, Wilcox A. The effect of occupational exposure to the mercury vapour on the fertility of female dental assistants. Occup Environ Med1994;51:28-34.
46. Gerhard I, Runnebaum B. The limits of hormone substitution in pollu¬tant exposure and fertility disorders. Zentralbl Gynaekol 1992;114:593-
602.
47. Sheiner EK, Sheiner E, Hammel RD, Potashnik G, Carel R Effect of occupational exposures on male fertility: literature review. Ind Health 2003; 41: 5-62.

Thank you for copying data from http://www.arastirmax.com