Pseudomonas aeruginosa pneumonia as cause of persistent cough in a child with cystic fibrosis: a case report
Journal Name:
- Türkiye Aile Hekimliği Dergisi
Keywords (Original Language):
| Author Name | University of Author | Faculty of Author |
|---|---|---|
Abstract (2. Language):
Cystic fibrosis (CF) is a disease which is caused by a mutation in the transmembrane conductance regulator gene, and displays autoso-mal recessive heredity. Cystic fibrosis trans-membrane regulator pro¬tein (CFTR) is required to regulate the components of sweat, diges¬tive fluids, and mucus. The prevalence of the disease is estimated as 1/2500-1/3500 in the white race. But the frequency of CF is not known for our country. Cystic fibrosis occurring in childhood, is a hereditary disease that proceeds with the dysfunction of all exocrine glands. The characteristic feature of the disease is the production of abnormal secretions in sweat, salivary, tracheobronchial, colon, uro-genital system and pancreatic exocrine glands. The significant clini¬cal signs of cystic fibrosis are chronic obstructive pulmonary disease and pancreatic insufficiency symptoms. Pseudomonas aeruginosa may lead to colonization, chronic and recurrent infections in patients with CF. In this article, a 10-year-old girl with CF having persistent cough related to acute exacerbation of chronic lung infection due to Pseudomonas aeruginosa colonization, has been presented.
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Abstract (Original Language):
Kistik fibrozis (KF), transmembran ileti regulator genindeki mutas-yon sonucu olujan ve otozomal resesif kalitim gosteren bir hastalik-tir. Kistik fibrozis transmembran regulator protein (KFTR) ter, sindi-rim sivilari ve mukus bilejenlerinin duzenlenmesinde gereklidir. Has-taligin sikligi beyaz irkta 1/2500-1/3500 civarindadir. Kistik fibrozisin ulkemizdeki sikligi ise bilinmemektedir. Kistik fibrozis gocukluk yaj-larinda ortaya gikan ve tum ekzokrin bezlerin fonksiyon bozuklugu ile seyreden kalitsal bir hastaliktir. Temel bozukluk ter, tukruk, solu-num sistemi, kalin barsak, urogenital sistem ve pankreas ekzokrin bezlerinden anormal sekresyonlarin olujumudur. Onde gelen klinik belirtiler, kronik obstruktif akciger hastaligi ve pankreas yetersizligi-ne ait bulgulardir. Pseudomonas aeruginosa KF hastalarinda koloni-zasyona, kronik ve tekrarlayan enfeksiyonlara neden olan bir bakte-ridir. Bu yazida kalici oksurugunun sebebi olarak, Pseudomonas ae-ruginosa kolonizasyonuna bagli kronik akciger enfeksiyonunun akut alevlenmesi tespit edilen kistik fibrozis tanisi almifl 10 yajinda bir kiz gocugu sunulmujtur.
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