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YAŞLILARDA ESER ELEMENTLER VE AİLE HEKİMLİĞİ AÇISINDAN KLİNİK ÖNEMİ

Trace Elements in Elderly Individuals and Their Clinical Significance in General Practice

Journal Name:

  • Türkiye Aile Hekimliği Dergisi

Publication Year:

  • 2007

Key Words:

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Abstract (2. Language): 
Objective: To estimate whether aging interferes or not with the mineral and micronutrient status of Mg, Zn and Cu in plasma and erythrocytes of healthy elderly individuals. Method: Fifty two old subjects over 80 years were examined. The data were compared to a control group of 63 healthy persons <65 years. Mg, Zn and Cu were measured in both plasma and RBC with atomic absorption spectrophotometer AAS - 3030 B Perkin Elmer. Results: Plasma and erythrocyte concentrations of Mg in healthy elderly were normal. While plasma Cu showed tendency to increase, intraerythrocytic (RBC) Cu was significantly decreased in the 80-89 years of age group in comparison to controls, respectively (11.53 ± 5,63 umol/l vs 16.67 ± 5.86 umol/l). Plasma Zn was in normal range, but showed tenden¬cy to decrease, while RBC Zn was significantly lower in both elderly groups in comparison to controls, respectively 80 - 89 years (158.44 ± 43.57 umol/l) and 90 - 102 years (150.04 ± 23.68 umol/l) vs (230.75 ± 51.36 umol/l). Conclusion: Study of RBC Cu, Zn and Mg instead of plasma gives more precise information for their actual status and reveals a deficiency of Cu and Zn in healthy individuals over 80 years. This gives us a basis to recommend food enrichment with Zn even in healthy elderly individuals without clinical symptoms.
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Abstract (Original Language): 
Amaç: Sağlıklı yaşlılarda, yaşlanmanın plazma ve eritrositlerde-ki Mg, Zn ve Cu'ın mineral ve mikro-besin elementi niteliğini etkileyip etkilemediğini saptamak. Yöntem: Yaşı 80'in üzerindeki 52 birey incelendi. Veriler <65 yaşındaki 63 sağlıklı bireyin sonuçlarıyla karşılaştırıldı. Plazma ve eritrositlerdeki Mg, Zn and Cu AAS - 3030 B Perkin Elmer atomik absorbsiyon spektrofotometresiyle ölçüldü. Bulgular: Sağlıklı yaşlılardaki Mg'un plazma ve eritrosit yoğunlukları normaldi. Buna karşılık 80-89 yaş grubunda plazma Cu'ı artma eğilimi gösterirken, eritrosit içi Cu kontrol grubuna göre anlamlı derecede azalmıştı, sırasıyla (11.53 ± 5.63 umol/l vs 16.67 ± 5.86 umol/l). Plazma Zn düzeyi normal değer ara¬lığında olmakla birlikte azalma eğilimi gösteriyordu. Eritrosit Zn'su ise her iki yaşlı grupta kontrol grubuna kıyasla anlamlı derecede azalmıştı; sırasıyla 80 - 89 yaş (158.44 ± 43.57 ± mol/l) ve 90 - 102 yaş (150.04 ± 23.68 umol/l) vs (230.75 ± 51.36 umol/l). Sonuç: Cu, Zn ve Mg'un plazma yerine eritrositlerdeki yoğun¬luklarının incelenmesi bu maddelerin halihazırdaki durumları hakkında daha kesin bilgi vermekte ve 80 yaşını aşkın sağlıklı bireylerde Cu ve Zn eksikliği geliştiğini ortaya koymaktadır. Bu bulgular, klinik belirti vermeyen, sağlıklı yaşlılarda besinlerin Zn ile zenginleştirilmesinin yararlı olacağını düşündürmektedir.
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159-164
  • Turkish

REFERENCES

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