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Helicobacter Pylori ve Gastrik Karsinogenez

Helicobacter Pylori and Gastric Carcinogenesis

Journal Name:

  • Uludağ Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2003

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Association between H.pylori and gastric carcinoma was defined through retrospective and prospective epidemiological studies following the discovery of H.pylori, and it was described as a first-degree risk factor for gastric cancer by International Agency for Research on Cancer, a WHO Study Group, in 1994. However, the role of H.pylori in carcinogenesis remains unclear. A proposed mechanism is as follows: H.pylori associated chronic gastritis causes mutagenic free oxygen radicals to increase in the epithelial tissue and antioxidants acting in mucosal defence system to decrease. This in turn leads to mutagenic free oxygen radicals eventually causing DNA damage. It was also demonstrated that H. pylori results in hyperproliferation by changing epithelial kinetics. Thus, it can be concluded that the association of hyperproliferation with free radicals causes damages in the cell which could play a significant role in triggering carcinogenesis.
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Abstract (Original Language): 
H.pylori ile gastrik karsinogenez arasındaki ilişki retrospektif ve prospektif çalışmalarla ortaya konmuş ve 1994 yılında WHO çalışma grubu olan “International Agency for research on Cancer” tarafından, H.pylori gastrik kanser için Ι. derece risk faktörü olarak tanımlanmıştır. Buna rağmen H.pylori’nin gastrik karsinogenezdeki rolü açıklanamamıştır. Muhtemel kabul edilen mekanizma ise; H.pyloriye bağlı kronik gastritis sonucu gastrik epitelde serbest oksijen radikalleri artmakta ve mukozal antioksidan defans sistemi azalmaktadır ve serbest oksijen radikalleri DNA hasarına neden olmaktadır. H.pylori aynı zamanda gastrik epiteliyal hiperproliferasyona neden olduğu gösterilmiştir. Bu nedenle artmış serbest oksijen radikalleri ile gastrik hiperproliferasyonun birlikteliğinin gastrik karsinogenezde tetikleyici rol oynayabileceği düşünülmektedir.
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  • 2
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  • Turkish

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