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İlaca Bağlı Miyopatiler

Drug-Induced Myopathies

Journal Name:

  • Uludağ Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2008

Key Words:

Keywords (Original Language):

Author Name
Abstract (2. Language): 
Drug-induced myopathy is among the most common causes of acquired muscle disease. The frequency of drug-induced myopathy is unknown, but this condition is likely to be common and certainly under-diagnosed. Drug-induced myopathy ranges from mild myalgias with weakness to chronic myopathy with severe weakness, or to massive rhabdomyolysis with acute renal failure. This toxicity is associated with creatine kinase concentrations. Withdrawal of the drug should rapidly lead to clinical improvement and normalization of serum creatine kinase concentrations.
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Abstract (Original Language): 
İlaca bağlı miyopati, edinsel kas inflamasyonu yapan hastalıklar içerisinde en sık görülen nedenler arasında yer almaktadır. İlaca bağlı miyopati görülme sıklığı bilinmemekte, yaygın olduğu halde tanı koymada zorluk çekilmektedir. İlaca bağlı miyopati, kas güçsüzlüğü ve miyalji gibi hafif semptomlardan, ciddi kas güçsüzlüğü ile birlikte olan kronik miyopatiden, rabdomiyoliz sonucu gelişen akut böbrek yetmezliğine kadar uzanmaktadır. Bu toksisite, kreatin kinaz yüksekliği ile ilişkilidir. Suçlu ilacın kesilmesiyle klinik bulgular ve serum kreatin kinaz seviyeleri hızlıca normale dönmektedir.
FULL TEXT (PDF): 
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  • 3
129-133
  • Turkish

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