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Renal Transplant Bekleyen Son Dönem Böbrek Yetmezlikli Diyaliz Hastalarında Helicobacter Pylori Sıklığı ve Gastrointestinal Semptomlarla İlişkisi

Helicobacter Pylori Prevalence and Its Relationship with Gastrointestinal Symptoms in Dialysis Patients with End Stage Renal Disease Waiting Renal Transplantation

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Abstract (2. Language): 
In this study, we aimed to determine the relationship between helicobacter pylori infection and gastrointestinal (GI) symptoms in renal transplant recipient. 8 women, 12 men totally 20 renal transplant recipient candidates were included in this study. All patients with GI symptoms were recorded, upper GI endoscopy were performed and helicobacter pylori (HP) infection frequency was investigated by using CLOtest. HP infection was determined in 11 of 20 patients included in this study. There was no statistically significant difference in demographic properties, GI symptoms, medications and laboratory findings between HP positive and negative groups. The most common gastroscopic finding, erosive bulbitis, was found in similar rate between these two groups. Although HP infection frequency was found 55% in our renal transplant recipient candidate dialysis patients, no relationship was found with the gastrointestinal symptoms.
Abstract (Original Language): 
Bu çalışmada Helicobacter pylori (HP) infeksiyonunun renal transplant alıcı adaylarındaki sıklığını ve gastrointestinal semptomlarla ilişkisini saptamayı amaçladık. Renal transplant alıcı adayı 8’i kadın, 12’si erkek toplam 20 olgu çalışmaya dahil edildi. Tüm olguların gastrointestinal yakınmaları kaydedilip üst gastrointestinal endoskopi yapıldı ve hızlı üreaz testi (CLOtest ® ) kullanılarak HP sıklığı araştırıldı. Çalışmaya dahil edilen 11 olguda HP infeksiyonu saptanırken 9’unda HP negatif bulundu. HP pozitif ve negatif iki gurubun demografik özellikleri, gastrointestinal semptomları, kullandıkları ilaçlar ve laboratuvar parametrelerinde anlamlı fark saptanmadı. En çok saptanan gastroskopik bulgu eroziv bulbitti fakat HP infeksiyonu olan ve olmayan iki gurupta da benzer oranda idi. Sonuç olarak renal transplant alıcı adayı diyaliz olgularımızda HP enfeksiyonu sıklığı %55 olmakla birlikte gastrointestinal semptomlarla ilişkili olmadığı sonucuna varıldı.
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REFERENCES

References: 

1. Sugimoto M, Sakai K, Imanishi J, Yamaoka Y. Prevalence of
Helicobacter pylori infection in longterm hemodialysis patients.
Kidney Int 2009; 75: 96–103.
2. Var C, Gultekin F, Candan F, et al. The effects of hemodialysis
on duodenal and gastric mucosal changes in uremic patients.
Clin Nephrol 1996; 45: 310–4. A. Ersoy, ark.
82
3. Shousha S, Arnaout AH, Abbas SH, et al. Antral Helicobacter
pylori in patients with chronic renal failure. J Clin Pathol 1990;
43: 397–9.
4. Jaspersen D, Fassbinder W, Heinkele P, et al. Significantly
lower prevalence of Helicobacter pylori in uremic patients than
in patients with normal renal function. J Gastroenterol 1995;
30:585–8.
5. Nakajima F, Sakaguchi M, Amemoto K, et al. Helicobacter
pylori in patients receiving longterm dialysis. Am J Nephrol
2002; 22: 468–72.
6. Parsonnet J. Helicobacter pylori. Infect Dis Clin North Am
1998; 12: 185–97.
7. Hamajima N, Matsuo K, Saito T, et al. Interleukin-1
polymorphisms, lifestyle factors, and Helicobacter pylori
infection. Jpn J Cancer Res 2001; 92: 383–9.
8. Marmara Sağlık Eğitim ve Araştırma Vakfı, 2007. TURHEP
Türkiye Helikobakter Pilori Prevalans Araştırması 2003
9. Luzza F, Imeneo M, Maletta M, et al. Helicobacter pylorispecific IgG in chronic haemodialysis patients: Relationship of
hypergastrinaemia to positive serology. Nephrol Dial
Transplant 1996; 1: 120–4.
10. Tokushima H. Role of Helicobacter pylori in gastro-duodenal
mucosal lesions in patients with end-stage renal disease under
dialysis treatment. Jpn J Nephrol 1995; 37: 503–10.
11. Nakajima F, Sakaguchi M, Amemoto K, et al. Prevalance of
Helicobacter pylori antibodies in longterm dialysis patients. Am
J Nephrol 2004; 9: 73–6.
12. Huang JJ, Huang CJ, Ruaan MK, et al. Diagnostic efficacy of
C-urea breath test for Helicobacter pylori infection in
hemodialysis patients. Am J Kidney Dis 2000; 36: 124–9.
13. Strid H, Simren M, Johansson AC, et al. The prevalence of
gastrointestinal symptoms in patients with chronic renal failure
is increased and associated with impaired psychological general
well-being. Nephrol Dial Transplant 2002; 17: 1434–9
14. Van Vlem B, Schoonjans RS, Struijk DG, et al. Influence of
dialysate on gastric emptying time in peritoneal dialysis
patients. Perit Dial Int 2002; 22: 32–8.
15. Min F, Tarlo SM, Bargman J, et al. Prevalence and causes of
cough in chronic dialysis patients: a comparison between
hemodialysis and peritoneal dialysis patients. Adv Perit Dial
2000; 16: 129–33.
16. Ozgur O, Boyacioglu S, Ozdogan M, et al. Helicobacter pylori
infection in haemodialysis patients and renal transplant
recipients. Nephrol Dial Transplant 1997; 12: 289–91.
17. Schoonjans R, Van VB, Vandamme W, et al. Dyspepsia and
gastroparesis in chronic renal failure: the role of Helicobacter
pylori. Clin Nephrol 2002; 57: 201–7.
18. Graham DY, Ginger ML, Peter DK, et al. Effect of treatment of
helicobacter Pylori infection on the long-term recurrence of
gastric and duodenal ulcer. A randomized controlled study. Ann
Intern Med 1992; 116: 705–8.

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