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Toprakta Tetrasiklin ve Sulfonamidlerin Ekofarmakokinetiği

Ecopharmacokinetics of Tetracyclines and Sulfonamides in Soil

Journal Name:

  • Uludag University Journal of The Faculty of Veterinary Medicine

Publication Year:

  • 2011

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The aims of this study were to evaluate the elimination of oxytetracycline, chlortetracycline, sulfadiazine and sulfamethoxazole from soil, and to investigate the influence of pH and the rainfall on elimination of the antibiotics. To detect antibiotic concentrations, leachate samples were collected from soil columns. The antibiotics were extracted by solid phase extraction and analysed by high performance liquid chromatography system. To determine elimination half-life of the antibiotics from soil and relationship between measured parameters, first-order kinetics and statistical analyses were applied to all collected data. Half-life of sulfadiazine and sulfamethoxazole in leachate waters 19 days after treatment was 0.24 hour and this was increased up to 2.25 hours sulfamethoxazole and 3.57 hours sulfadiazine 33 days after treatment. A half-life for tetracyclines was not detected, since there was not consistent trend for the transport of tetracyclines between soil and water compartments. The results of regression analyses showed that the concentrations of antibiotics in the same group changed at the same rate. The pH of leachate samples was positively influenced by increases in rainfall and days after treatment. A significant relationship was not found between the antibiotic concentrations and both pH and rainfall.
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Abstract (Original Language): 
Bu çalışmanın amacı oksitetrasiklin, klortetrasiklin, sulfadiazine ve sulfametoksazolun topraktan eliminasyonunu incelemek ve pH ile yağışın antibiyotiklerin eliminasyonuna etkisini araştırmaktır. Antibiyotik miktarlarını belirlemek için toprak kolonlarından sızıntı suyu örnekleri toplandı. Antibiyotikler katı faz ekstraksiyon yöntemiyle ekstrakte edildi ve yüksek performanslı sıvı kromatografi ile analiz edildi. Antibiyotiklerin topraktan yarı-ömrünü ve ölçülen parametreler arasındaki ilişkiyi belirlemek için toplanan tüm verilere birinci derece kinetiği ve istatistiksel analiz uygulandı. Sulfadiazin ve sulfametoksazolun uygulamadan 19 gün sonra sızıntı sularındaki yarı-ömrü 0.24 saatti ve bu süre uygulamadan 33 gün sonra sulfametoksazol için 2.25 saate, sulfadiazin için 3.57 saate kadar arttı. Tetrasiklinlerin toprak ve su kompartmanları arasında tutarlı bir geçişi olmadığından tetrasiklinler için bir yarı-ömür tespit edilemedi. Regresyon analizi sonuçları aynı gruptaki antibiyotik miktarlarının aynı oranda değiştiğini gösterdi. Sızıntı suyu örneklerinin pH’sı yağış ve uygulama süresinden pozitif şekilde etkilendi. Antibiyotik miktarları ile pH ve yağış arasında önemli bir ilişki bulunamadı.
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  • Turkish

REFERENCES

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