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SIMULTANEOUS ESTIMATION OF AMLODIPINE AND INDAPAMIDE IN COMBINED DOSAGE FORM USING DERIVATIVE SPECTROPHOTOMETRIC METHOD

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Abstract (2. Language): 
A simple and reproducible spectrophotometric method, requiring no prior separation, has been develo ped for the estimation of Amlodipine and Indapamide in combined dosage form. First order derivative spectroscopy method was adopted to eliminate spectral interference, using 237.40 nm and 241.40 nm as zero crossing points for Amlodipine and Indapamide respectively. Methanol was used as a solvent. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method.

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