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TÜRKİYE'DEKİ INFLAMATUAR BARSAK HASTALARINDA HLA-DRB1 ALELLERİNİN DAĞILIMI

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The distributİon of HLA DRBI alleles in inflammatory bowel disease patients in Turkey. Re-ceııtly deseribed distinet assocîations of HLA elass II genes with ulserative colİtİs and Crohn's disease suggest a genetic heterogencity of disease susceptİbilily. In thİs study, HLA-DRBİ alleles werc investigated in a population of UC (n=59) and CD (n=15) patients from Turkey compared to controls (n=244) with molecular genotyping by polymerase chain reaction and sequence specİfic oligonucleotide hybridization. We observed a positive association with thc HLA-DRB 1*1502 allele (10/59 vs. 16/244, p = 0.02, OR: 2.9 ) and a negative association with theDRBl*13 allele (7/59 vs. 64/244, p = 0.03, OR: 0.38) in patients with UC, DRB1*08 allele inereased sİgnificantly in patients with Crohn's disease compared to controls. These results support the hypothesis that UC and CD may be genetically distinet disorders. DRB1*1502 allele or haplotype bearİng it, is assocİated with UC susceptibİIity in Turkish population
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Abstract (Original Language): 
Ülscratif kolit (ÜK) ve Crohn hastalığı (CH) ile HLA sınıf II genleri arasında son yıllarda tanımlanan farklı ilişkiler hastalığa yatkınlıkta genetik çeşitlilik olduğunu düşündürmektedir. Bu çalışmada, Türkiye popülasyonunda CH (n=15) ve ÜK (n=59) hastalarındakt HLA-DRBİ alelleri sağlıklı kontrollerle (n=244) karşılaştırılarak incelendi. Polimeraz zincir reaksiyonu ve diziye özgü oligonükleolid hibridizasyonla genotipleme metodu uygulandı. Kontrol grubuna kıyasla ÜK lî hastalarda DRB1*1502 aleli ile pozitif (10/59 vs. 16/244, p = 0.02, OR: 2.9 ), DRB1*13 ile negatif (7/59 vs. 64/244, p = 0.03, OR: 0.38) ilişki olduğu gözlendi. Buna karşın Crohn hastalarında DRB1*08 sikliği kontrole göre anlamlı bir artış gösterdi. Sonuçlar, ÜK vc CH nm genetik olarak farklı hastalıklar olduğu hipotezini desteklemektedir. Türkiye popülasyonunda ÜK hastalığına yatkınlıkla direkt DRB 1*1502 alcîİ veya bu alcli taşıyan haplotİpin ilişkİH olabileceği İleri sürülebilir.
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  • 2
128-131
  • Turkish

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