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Vitamin B12 eksikliği epilepsi ilişkisi: İki vaka sunumu

Vitamin B12 deficiency associated with epilepsy: two cases

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2005

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The prevalence of epilepsy is 0.5-1% in childhood. Vitamin B12 deficiency is very rare etiologic cause of epilepsy. Abnormal EEG finding has found in the patient with cobalamin deficient. It has been reported that decreasing of IL-6 levels in cerebrospinal fluid causes neuropathological effects in cobalamin deficient rats. We present two patients with megaloblastic anemia and developing epilepsy during their follow up. Patients who represented with abnormal neurological findings and convulsions, besides the other causes, vitamin B12 deficiency must be investigated.
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Abstract (Original Language): 
Çocukluk çağında epilepsi prevalansı % 0.5-1 arasında değişmekte ve etyolojisinde vitamin B12 eksikliği nadiren suçlanmaktadır. Kobalamin eksikliği olan hastalarda anormal EEG bulguları saptanmıştır. Deneysel kobalamin eksikliği oluşturulan ratlarda ise nöropatolojik bulgular tespit edilmiş olup, bu durumun BOS IL-6 seviyesinin azalmasına bağlı olduğu düşünülmektedir. Bu yazıda kliniğimizde megaloblastik anemi tanısı alan ve izleminde epilepsi saptanan iki hasta sunulmuştur. Anormal nörolojik bulguları ve konvülziyonları olan süt çocuğu dönemindeki hastalarda diğer nedenler yanında B12 vitamin eksikliğinin de araştırılması uygundur.
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  • 4
49-52
  • Turkish

REFERENCES

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