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Ratlarda kadmiyumun pankreasa etkileri

Effects of cadmıum on pancreas ın rats

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2005

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Cadmium is a metal which causes toxic effects in various organs. In some cases, several metals like zinc cause acute pancreatitis. Therefore, we aimed to investigate possible adverse effects of cadmium in rat pancreas. Study groups were designed as control and cadmium groups. Cadmium groups were given 15 ppm cadmium chloride for 30 days via drinking water. In the end of the study, blood samples were taken under urethane anesthesia. In each sample, serum amylase and lipase enzyme activities were measured. When compared with control group, both serum lipase and amylase enzyme activities were increased in cadmium group but this was not significant. furthermore, in cadmium group there were some congestion focuses and increase in connective tissue. We have concluded that cadmium seems not to lead biochemically active pancreas damage, however some mild histopathological changes can be seen when cadmium is administered to rats at this dose level.
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Abstract (Original Language): 
Kadmiyum pekçok organ üzerinde zararlı etkileri olan bir metal olup, diğer bazı metaller gibi pankreatite yol açabilmektedir. Bu çalışmada, ratlarda kadmiyumun pankreas üzerindeki zararlı etkilerini araştırmayı amaçladık. Çalışma grupları, kontrol ve kadmiyum grupları şeklinde düzenlendi. Kadmiyum grubuna içme suyu ile 30 gün boyunca 15 ppm dozunda kadmiyum içirildi. 30. günün sonunda, üretan anestezisi altında ratlardan kan örnekleri alındı. Alınan serum örneklerinde, amilaz ve lipaz aktiviteleri ölçüldü. Kadmiyum uygulanan grup kontrol grubuyla karşılaştırıldığında, kadmium uygulanan grubun kan kadmiyum seviyelerinde anlamlı bir artışın meydana geldiği (P<0.05), amilaz ve lipaz aktivitelerinin artmasına rağmen, bu artışın anlamlı olmadığı görüldü (P>0.05). Histopatolojik incelmede ise, kadmiyum uygulanan grubun pankreas preperatlarında kanama odaklarının ve bağ dokusu artışının olduğu tespit edildi. Sonuçta elde edilen bulgular, uzun süre içme suyu ile düşük doz kadmiyum verilen ratlarda biyokimyasal olarak aktif pankreatitin gelişmediği, ancak histopatolojik incelemede göreceli olarak hafif patolojik değişikliklerin olabileceğini düşündürdü.
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  • 3
27-30
  • Turkish

REFERENCES

References: 

1.
Mollaoğl
u H, Yılmaz HR, Gökalp O, Altuntaş İ. Methidation'un pankreas üzerine etkileri: Vitamin E ve C'nin rolü. Van Tıp Dergisi. 2003;10(4):98-100, E
2. Sahin I, Onbasi K, Sahin H, Karakaya C, Ustun Y, Noyan T. The prevelance of pancreatitis in organophosphate poisonings. Human and Experimental Toxicology. 2002;21:175-177.
3.
Gökal
p O, Mollaoğlu H, Yılmaz HR, Altuntaş İ. Organofosfat insektisit Fenthion'un rat amilaz ve lipaz enzimleri üzerine etkisi: Vitamin E ve C'nin rolü. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 2003:10-(2)/2 1-23.
4. Karam JH, Lewitt PA, Young CW, Nowlain RE, Frankel BJ, Fujiya H, Freedman ZR, Grodsky GM. Insulinopenic diabetes after rodenticide (Vacor) ingestion: a unique model of acquired diabetes in man. Anesthesia 1999;54:1073-1088. Diabetes. 1980;29:971-
978.
5. Gokalp O, Buyukvanlı B, Cicek E, Ozer MK, Koyu A, Altuntas I, Koylu H. The effects of diazinon on pancreatic damage and ameliorating role of vitamin E and vitamin C.EPesticide Biochemistry and Physiology. 2005;81:123-128.
6. Kaputlu I, Ozdem S, Sadan G, Gokalp O. Effects of diabetes on non-adrenergic, non-cholinergic relaxation induced by GABA and electrical stimulation in the rat isolated duodenum. Clinical and Experimental Pharmacology and Physiology. 1999;26(9):724-728.
7. Sai P, Boillot D, Boitard C, Debray-Sachs M, Reach G, Assan R. Pentamidine, a new diabetogenic drug in laboratoryrodents. Diabetologia. 1983;25(5):418-423.
8. Sileo L, Nelson Beyer W, Mateo R. Pancreatitis in wild zinc-poisoned waterfowl. Avian Pathol.
2003;32(6):655-656
9. Vodela JK, Renden JA, Lenz SD, McElhenney WH, Kemppainen BW..Drinking water contaminants (arsenic, cadmium, lead, benzene, and trichloroethylene). 1. Interaction of contaminants with nutritional status on general performance and immune function in broiler chickens. Poult Sci. 1997 Nov;76(11):1474-1492.
S.D.Ü. Tıp fak.
Derg
. 2005:12(3)/ 27-30
30
Gökalp, Kadmiyum ve pankreas
10. Harputluoglu MM, Kantarceken B, Karincaoglu M, Aladag M, Yildiz R, Ates M, Yildirim B, Hilmioglu F. Acute pancreatitis: an obscure complication of organophosphate intoxication. Human and Experimental Toxicology 2003; 22(6):341-343.
11. Stevens T, Conwell DL, Zuccaro G. Pathogenesis of chronic pancreatitis: an evidence-based review of past theories and recent developments. American Journal ofGastroenterology2004;99(11):2256-2270.
12. Barlas A, Cevik H, Arbak S, Bangir D, Sener G, Yegen C, Yegen BC. Melatonin protects against pancreaticobiliary inflammation and associated remote organ injury in rats: role of neutrophils. Journal of Pineal Research 2004;37(4):267-275.
13. Shimada H, Funakoshi T, Waalkes MP. Acute, nontoxic cadmium exposure inhibits pancreatic protease activities in the mouse. Toxicological Science 2000; 53(2):474-
480.
14. Bilgen I, Oner G, Edremitlioglu M, Alkan Z, Cirrik S. Involvement of cholinoceptors in cadmium-induced endothelial dysfunction. J Basic Clin Physiol Pharmacol. 2003;14(1):55-76. J Basic Clin Physiol Pharmacol. 2003;14(1):55-76.
15. T.D. Dressel, R.L.Jr. Goodale, B. Zweber and J.W. Borner, The effect of atropine and duct decompression on the evolution of Diazinon-induced acute canine pancreatitis, Annals ofSurgery 1982;195: 424-434.
16. Manca D, Ricard AC, Trottier B, Chevalier G Studies on lipid peroxidation in rat tissues following administration oflow and moderate doses of cadmium chloride. Toxicology 1991; 67:303-323.
17. Mittal CK, Harrell WB, Mehta CS Interaction ofheavy metal toxicants with brain constitutive nitric oxide synthase. MolecularCellBiochemistry 1995; 149-150:
263-265.
18. Muller T, Schuckelt R, Jaenicke L Cadmium/zinc-metallothionein induces DNA strand breaks in vitro. Archives Toxicology 1991; 65:20-26.

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