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Karaciğer Nakli Sonuçları Üzerinde Kan Transfüzyonlarının Etkisi ve Transfüzyon Gereksinimini Etkileyen Faktörler

Effect Of Blood Transfusıon On Lıver Transplant’s Outcomes And Predıctıve Factors On Transfusıon Requırement

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2008

Key Words:

Keywords (Original Language):

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Abstract (2. Language): 
BACKROUND: The aim of this study is to identify the preoperative variables associated with prediction of intraoperative blood transfusion as well as analyze the influence of intraoperative blood transfusion on postoperative outcomes. MATERIALS and METHOD: Between June 2004 and May 2006 a total of 81 liver transplantation (16 CDLT, 65 LDLT) were performed on 81 patients (56 male and 25 female) who had end stage liver at our hospital. The patients were split in two groups, as similar previous studies. High transfusion group (HTG) (>4 RBC) was compaired againts the low transfusion group (LTG) (< 4RBC). Univariate analysis was performed with the independent student’s t- test for quantitative variables and chi-square test was used for qualitative variables after data categorization and calculation. RESULTS: The mean transfused units of red blood cell (RBC) was 5.41. Patient’s age, availabity of HCV and elevated Child score had significance for intraoperative blood transfusion requirement. Postoperative mortality and reoperation rate had significantly elevated in HTG patients also HTG patients had more infectious. CONCLUSION: We concluded that high blood transfusion has major effect on posttransplant complications and postoperative mortality.
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Abstract (Original Language): 
AMAÇ: İntraoperatif kan transfüzyon ihtiyacı üzerindeki preoperatif hasta karekteristiklerinin etkisini araştırmak ve aynı zamanda kan transfüzyonunun postoperatif mortalite ve morbiditeye etkilerini değerlendirmek. MATERYAL ve METOD: Haziran 2004 ile Mayıs 2006 tarihleri arasında kliniğimizde son evre karaciğer hastalığı olan 16’sı kadaverik ve 65’i canlıdan olmak üzere toplam 81 hastaya karaciğer transplantasyonu uygulandı. Hastalar daha önceki çalışmalarda olduğu gibi 2 gruba ayrıldı). Yüksek transfüzyon yapılmış gurup (YTG) (>4 ünite eritrosit süspansiyonu) ve düşük transfüzyon yapılmış gurup (DTG) (<4 ünite eritrosit süspansiyonu). Dataların kategorizasyonu ve hesaplanmasından sonra kantitatif parametreler independent student’s t- test, kalitatif parametreler ise chi-squared test ile değerlendirildi. BULGULAR: Ortalama transfüze edilen eritrosit süspansiyonu 5.4 ünite idi. İntraoperatif kan transfüzyonu gereksinimi üzerinde hasta yaşı, primer hastalık olarak HCV, hastanın Child skoru anlamlı parametreler olarak saptandı. YTG hastalarda postoperatif reoperasyon ve mortalite oranı anlamlı düzeyde daha yüksek bulundu. Ayrıca YTG hastalarda postoperatif enfeksiyon gelişimi daha fazla idi. SONUÇ: Bu araştırmada yüksek kan transfüzyonunun posttransplant komplikasyonlar ve mortalite üzerinde önemli bir etken olduğu sonucuna varılmıştır.
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  • 2
87-91
  • Turkish

REFERENCES

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