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Epinefrin Ve Soğuk Stresinin Tirozin Hidroksilaz Enzim Aktivitesi Üzerine Etkisi

Effects of Epinephrine And Cold Stress On Tyrosine Hydroxylase Enzyme Activity

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
It has been known that the cold stress inducts the adrenergic system and increases tyrosin hydroxylase (TH) enzyme activity which has a key role on the catecholamine synthesis. In this study, the effects of epinephrine and cold stress on TH enzyme activity and total RNA level of rat adrenal medulla, heart and hypothalamus were examined comparatively. It was found that there was clear increase of TH enzyme activities and total RNA concentrations in three tissues with administration of epinephrine. It was also observed that there was an increase in TH enzyme activity at the end of the 48-hour cold stress treatment. Similarly, total RNA concentration was increased in heart and hypothalamus except adrenal medulla.
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Abstract (Original Language): 
Soğuk stresinin memeli hayvanlarda adrenerjik sistemi uyardığı ve katekolamin sentezinde anahtar rolü olan tirozin hidroksilaz (TH) enzim aktivitesini artırdığı bilinmektedir. Bu çalışmada epinefrin ve soğuk stresinin sıça n adrenal medulla, kalp ve hipotalamus dokularında TH enzim aktivitesi ve total RNA seviyesi üzerine etkileri karşılaştırmalı olarak araştırıldı. Epinefrin uygulaması ile her üç dokuda TH enzim aktivitesi ve total RNA miktarında belirgin artış kaydedildi. 48 saat soğuk stresi uygulaması sonucunda her üç dokuda TH enzim aktivitesinin arttığı belirlendi. Benzer şekilde adrenal medulla hariç kalp ve hipotalamus total RNA miktarında da artış kaydedildi.
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  • Turkish

REFERENCES

References: 

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