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Nedocromil sodium'un ozonun neden olduğu solunum fonksiyon değişiklikleri üzerine etkisi

Nedocromil Sodium Worsens Ozone-Induced Lung Function Changes in Healthy Non-Smoking Subjects

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1998

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Ozone exposure can result in acute reversible restrictive and obstructive lung functions changes. The mechanism for these changes may be related to release of neuropeptides from sensory nerve endings in the airway. Nedocromil sodium may act by inhibiting neuropeptide release and thus could possibly prevent ozone-induced decrements in lung function. Four responders (non-smoking volunteers with >15% decline in FEV] to ozone exposure) and 5 non-responders (<5% decline in FEV] to ozone) were exposed to 30 minutes of exercise in 0.25-0.30 ppm ozone after receiving 2 days of nedocromil sodium with the last dose immediately before O3 exposure. In both the responders and non-responders, pre-treatment with nedocromil sodium subsequent ozone exposure resulted in greater decreases in FEV] and FVC than with ozone exposure alone (p<0.05). Nedocromil sodium which is thought to work in part by inhibiting release of neuropeptides from airway sensory nerve endings worsened O3 induced pulmonary function changes in nonsmoking volunteers. [Journal of Turgut Özal Medical Center 1998;5(1):34-39]
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Abstract (Original Language): 
Hava kirliliği sonucu oluşan ozon, akciğerleri etkiler ve solunum fonksiyonlarında akut reverzibl restriktifve obstrüktif tipte değişiklikler meydana çıkabilir. Bu değişikliklerin hav ay ollar ındaki sinir uçlarından nöropeptid salgılanması sonucu olabileceği düşünülmüştür. Nedocromil sodium (NS)'un etki mekanizmaları arasında nöropeptid salınım inhibisyonu bildirilmektedir ve ozonun sebep olduğu solunum fonksiyon bozukluklarına karşı koruyucu etkisi olabileceği düşüncesi ile çalışmamız düzenlenmiştir. Araştırma; 4'ü ozondan etkilenen (FEV] 'de azalma >%15) ve 5'i ozondan etkilenmeyen (FEV]'de azalma <%5) toplam 9 sigara kullanmayan gönüllüde yapıldı. Herb ir ine 2 gün NS tedavisi (14 mg/gün) verildikten sonra özel olarak hazırlanmış odacık içinde, 30 dakika egzersiz ile 0.25-0.30 ppm ozon uygulandı. Her iki grupta da NS ile tedavi edilen olgularda; FVC'de anlamlı azalma saptandı (p<0.05). Sonuçlarımıza göre; nedocromil sodium 'un ozonun solunum fonksiyonları üzerindeki olumsuz etkilerini arttırdığı kanısına varıldı. [Turgut Özal Tıp Merkezi Dergisi 1998;5(1):34-39]
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  • Turkish

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