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Allojenik kemik iliği transplantasyonu sonrası kronik graft-versus-host hastalığına bağlı korneal perforasyon

Corneal perforation due to chronic graftversus-host disease after allogenic bone marrow transplantation

Journal Name:

  • Gülhane Tıp Dergisi

Publication Year:

  • 2006

Key Words:

Keywords (Original Language):

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Abstract (2. Language): 
Dry eye associated with chronic graft-versus-host disease is the most frequently observed complication after allogenic bone marrow transplantation. The other important ocular complications are recurrent corneal epithelial defects, corneal ulcer and corneal melting. A 25-year-old female patient admitted with the complaints of stinging and burning sensation in her both eyes. The patient had allogenic bone marrow transplantation with the diagnosis of chronic myelocytic leukemia two years ago. Examination of the patient revealed punctate epithelial keratopathy, dry eye and posterior subcapsular cataract in her both eyes. We determined common skin dryness, dermatitis and Cushingoid face in her examination. In this article a case of dry eye and corneal perforation developing due to chronic graft-versushost disease after allogenic bone marrow transplantation is presented, and combination treatment of tacrolimus, steroid and hyperbaric oxygen therapy performed after primary surgery is discussed.
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Abstract (Original Language): 
Kronik "graft-versus-host" hastalığı ile ilişkili kuru göz, allojenik kemik iliği transplantasyonu sonrası en sık görülen komplikasyonlardandır. Diğer önemli göz komplikasyonları, tekrarlayan kornea epitel defektleri ile kornea ülseri ve korneal erimedir. Yirmibeş yaşında bayan hasta her iki gözde yanma ve batma şikayetleri ile başvurdu. İki yıl önce kronik myelositik lösemi nedeni ile allojenik kemik iliği transplantasyonu uygulandığı öğrenildi. Hastanın muayenesinde her iki gözde yaygın punktat epitelyopati, kuru göz ve arka subkapsüler katarakt saptandı. Muayenesinde ciltte yaygın bir kuruluk ile dermatit tablosu ve Cushingoid yüz hatları mevcuttu. Bu yazıda allojenik kemik iliği transplantasyonu sonrası kronik "graft-versus-host" hastalığına bağlı kuru göz, takiben korneal erime ve perforasyon görülen hastanın klinik seyri ve tedavileri sunulmakta, primer tamir sonrası uygulanan steroid, takrolimus kombinasyonu ve hiperbarik oksijen ile tedavi sonuçları tartışılmaktadır.
FULL TEXT (PDF): 
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  • 3
166-168
  • Turkish

REFERENCES

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