Buradasınız

RENAL TRANSPLANT ASYONLU HASTADA SİKLOSPORİN TEDAVİSİNE BAĞLI GINGIVAL HİPERPLAZİ. Bir Vaka Raporu

GINGIVAL HYPERPLASIA IN RENAL ALLOGRAFT RECIPIENT RECEIVING CYCLOSPORIN: A CASK REPORT

Journal Name:

Publication Year:

Keywords (Original Language):

Abstract (2. Language): 
Cyclosporin is a potent imınunosupprcsivc drug is widely used in kidney, liver, heart and other organ transplants, because it is better tolerated than conventional agents such as corticosteroids and eyctotoxic drugs. Despite the overall improvement in graft survival for organ transplants, many adverse effects arc associated with this drug. One of the most important adverse effects of cyclosporin is gingival overgrowth. Problems associated with this condition may include poor aesthetics, eating difficulties and fetor oris. This report relates a case of severe gingival hyperplasia in a 25 year old male who had received cyclosporins therapy in conjunction with a kidney transplant. This case was treated by gingiveetomy at two appointments, under antibiotic coverage. The oral condition after surgery was satisfactory. The patient is complying with the oral hvgicne procedures and his periodontal status i.s still satisfactory after 8 months ol the surgery,
Abstract (Original Language): 
Siklosporin, korlikosteroidler vc sitolnksıkle r gibi konvasyoncl ilaçlardan dalın iyi tolere edildiğinden dolayı böbrek, karaciğer, kalp vc diğer organ transplantasyonunda sıklıkla kullanılan immiinnsupresif ilaçtır. Siklnsporinin organ transplantasyonunda başarıyla kullanılmasına ragmen bir çok yan etkileri vardır, ün önemli yan etkilerinden biri gingival hiperplazidir. Bu durum kötü estetik, yeme güçlüğü vc kötü ağız kokusu ile birlikledir. Bu makalede renal transplantasyon yaptırmış olan 25 yaşındaki erkek hastada, siklosporin tedavisine bağlı gingival hiperplazi olgusu sunulmuştur. Hastaya antibiyotik hastası altında 2 seansta gin^ivektomi operasyonu uygulandı. Cerrahî işlemden sonra oral durum memnuniyet vericiydi. Oral hijyen önerisinde bulunulan vc her ay kontrolü yapılan hastamızın operasyon sonu S. ayda periodontal dokuların sağlıklı olduğu, nüksün görülmediği gö/.lendi
64-68

REFERENCES

References: 

1. Adams, D.and Davics,G.:Gingival hyperplasia associated with cyclosporin A: a report of two cases. British DcntaUoumal 157,89-90,1984.
2. Asahara Y, Nishimura F, Yamada H, Namishi K, Kataoka M,Kidn .1, Nagata T,Mumyama Y.: Mast cells are not involved in the development of cyclosporin A-induccd gingival hyperplasia: a study with mast cell-deficient mice. J Periodontol Jul; 71 (7): 1117-20, 2000¬3. Ayanoğlu CM, Lesty C: Cyclosporin A-induced
gingival overgrowth in the rat: a histological, ultrastructural and histomorphomctric evaluation. J Periodontol Res Jan; 34(1): 7-15, 1999.
4. Calne, R.Y. Thiru,S., Monaster, P., Craddock, G. N.. White. DJ-G-, Evans.D.B.,Dunn, DC, Penllovv,
BraO.and Rolles, K.: Cyclosporin-A in patients receiving renal allografts from cadaver donors. Lancet 1, 1323-1327, 1978.
5. Daley, T.D.. Wysocki, G-P-and May.C,: Clinical and pharmacological correlations in cyclosporin-in d need gingival hyperplasia. Oral Surgery, Oral Medicine and Oral Pathology 62,417-421,1986,
6. Friskopp, J., and Klintmalm, G.: Gingival enlargement. A comparison between cyclosporins and azathioprine treated renal allograft recipients. Swedish Dental Journal 10,85-92,1986,
7. Hancock RH and Swan RH; Nifbnipine- induced gingival overgrowth. J Clin Periodontal 19, 12-14, 1992.
8. Kantarci A, Cebeci E, Tuncer O, Carin M, Firatli E.: Clinical effects of periodontal therapy on the severity of cyclosporin A-induced gingival hyperplasia, J Periodontol Jun;70(6):587-93,1999.
9. King, G. N., Fullinfaw R, Higgins T J .Walker
RG, Francis DMA and Wiesenfeld D: Gingival Hyperplasia in renal allograft recipients receiving cyclosporin-A and calcium antagonists. Journal of Clinical Periodontnlgy 20286-293,1993.
10. Me (iiiw, I'., Lam, S, and CoatesJ Cyclosporin-induccd gingival overgrowth; coirelalion with dental plaque scores, gingivitis scores and cyclosporin levels in serum and saliva. Oral Surgerv, Oral Medicine and Oral Pathology 64293-297,1987,
11. Rateitschak-pluss, E. M,, Hefti, A,, Lortschcr, R. and Thiel, G.: Initial observations that cyclosporin A induces gingival enlargement m man. Journal of Clinical Pcriodontolgy. 10,237-246,1983.
12. Rostock. M. H., Fry, H.R. and Turner, J.E.: Severe gingival overgrowth associated with cyclosporine Therapy. Journal of Pcriodontolgy 57.294-299,1986.
13. Seymour R A and Jacops D J; Cyclosporine and the gingival tissues. Journal of Clinical Periodontolgy 19,l-li,l992,
67
Atatürk Üniv.Diş Hek.FakDcrg. GU:11, Sayi:l, Sayfa:64-fi"R.200l
ÜNLÜjPEK
14. Seymour R A and Smilh: The effect ora plaque control programme on the incidence and severity of cyclosporine -induced gingival changes, journal of Clinical PeriodorUolgy 18,107 110.1991.
15. Seymour R A , Smith D. G. and Rogers S.K.: The comparative effects of azathioprine and cyclosporin on some gingival health parameters of renal transplant patients. Journal of Clinical Periodontolgy 14,610-613,1987.
16. Thompson , J M, Seymour R A, Ellis J: The periodontal problems and management of the renal transplant patient. Ren Fail 16,6: 731-745,1994.
17. Tyldesley, W R and Rotter, K.: Gingival hyperplasia induced by cyclosporin-A British Dental Journal 157,305-309,1984.
18. Yamada 11. Nishımura F, Naruishi K, Chou HH, Takashiba S, Albright GM, Narcs S, Lacopino AM, Murayaına Y,: Phenytoin and cyclosporinA suppress the expression of MMP-I, TIMP-I, and cathepsin L, but not caphepsin B in cultured gingival fibroblasts. .1 Periodontol Jun;7I (6): 955-60,2000.'

Thank you for copying data from http://www.arastirmax.com