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KOBAY ADRENAL KORTEKSlNİN ERKEN VE GEÇ GEBELİK DÖNEMLERİNDE KIYASLI YAPIST: MORFOMETRİK VE IŞIK MİKROSKOBİK ÇALIŞMA

COMPARATIVE STRUCTURE OF GUINEA PIG ADRENAL CORTEX IN EARLY AND LATE GESTATIONAL PERIODS: A MORPHOMETRY AND LIGHT-MICROSCOPIC STUDY

Journal Name:

  • Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
In this study, it was aimed to determine probable structural changes that may occur during gestation by researching the adrenal cortices of guinea pigs in different gestational periods. For this aim the adrenal cortices of the animals at day 35 and day 60 of gestation were compared with both tho.se of nonpregnants and each other morphomclneally and light-microscopically. The adrenal glands of pregnants were bigger than those of nonpregnants macroscopicallv- On the preparations, it was observed that this getting large was particularly at cortex. The thicknesses of total coitcs and /.»mı glomerulosa (ZG) and combined thickness of zonae fascieulata and reticularis (ZF+ZR) were increased in all pregnant animals compared to those of nonpregnants (p<0,05). In comparison with controls, the number of inner ZF- and outer ZR-cells of animals at day 35 of gestation were less (p<0,05). In the pregnants at day 60 of gestation, the cell counts per unit area of all cortical layers were more than in other two groups (p<0,05). In pregnants. adrenal capsule's deep part adjacent to ZG was with more cells than in controls; in ZG and outer ZF of pregnants, more mitotic figures were observed than in those of controls. Particularly in the pregnants al day 60 of gestation, the transition zone between ZG and ZF had much more cells, and the nuclei of ZG- and outer ZF-cells were bigger than in nonpregnants. The intracytoplasnnc large lipid vacuoles which are found in outer ZF normally were seen in inner ZF- and outer ZR-cells of pregnants also; in the pregnants at day 35 of gestation, these cells were full of large lipid vacuoles; but in the pregnants al day 60 of gestation, these lipid vacuoles were less and smaller compared with those of the other pregnant group. Apart from these, more hpofusein pigment granules were observed in deeper cortical cells of pregnants than m those of controls. In conclusion, it was thoughl thai the reason of structural changes occurmg in the adrenal cortex of pregnants may be the stimulation of adrenal cortex by adrenocorticotropic hormone released from pSacenta and excessively Trom hypophysis and/or adrenal gland by means of increased estrogen hormone in pregnancy.
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Abstract (Original Language): 
Du araştırmada, farklı gebelik dönemlerindeki kobayların adrenal kortckslcrini inceleyerek, gebelik boyunca gelişebilecek olası yapısal değişiklikleri saptamak amaçlandı. Bu turaçla, 35 ve 60 günlük gebe kobayların adrenal kortckslcrı, hem kontrol grubu ile hem de kendi aralarında morfometrik ve ışık mikroskobik düzeyde kıyaslandı. Gebe kobayların adrenal besleri, kontrole kıyasla makroskobik olarak daha büyüktü, l'reparasyonlarda hu büyümenin özellikle kortekste olduğu saptandı. Total korteksin, zona glomerulo/.a (ZG)* nın ve z.ona l'asikülata ile zona reiıkülarısin birlikte (ZF+ZR) kalınlıkları her iki gebe grubunda da kontrole kıyasla artmıştı (p<0,05). Konimle kıyasla, 35 günlük gebelerde iç-ZF'dcki vc dış-ZR' deki hücre sayısı daha azdı (p<0.05). Altmış günlük gebelerde ise, bütün koıteks tabakalarındaki birini alana düşen hücre sayısı, diğer iki gruptakinden daha fazla bulundu (p<0,0.î). Gebelerde, adrenal be/, kapsiilasınıtı ZG' ye bitişik derin bölümleri daha bol hücreli görüldü; ZG' de ve dıs-ZF' dc daha fa/la mıtoz figürüne rastlandı. Özellikle 60 günlük gebelerde, ZG ile dış-ZF' deki parankim hücrelerinin niikletısları daha iri vc ZG ile ZF arastndaki bölüm daha bol hücreliydi. Normalde dış-ZF' de buhınan intrasıtopkızmık iri lipid vakuollcri, gebelerde iç-ZF ve dı^-ZR." nin hücrelerinde dc bolca gözlendi; 35 günlük gebelerde, söz edilen hücreler iri lipid vakııollcrlyle tıkabasa doluydu; 60 günlük gebelerde ise bu lipid vakuolleri, diğer gebe grubtındakine kıyasla daha kuç-uk ve sayıca daha aydı. Bunların yanı sıra, gebelerin derin koıteks hücrelerinde daha fazla lipofussin pigment granüllen i/.lendi. Sonuç olaısk, gebe kobayların adrenal korteksinde saptanan bu değişikliklerin, gebelikte yükselen ostrojen hormonunun etkisiyle hipofizden vc/veya adrenal bezden salgılanması artan ve aynı zamanda plasentadan du salgılanan adrenokorlikotrop hormonun adrenal koıteksı uyarmasından kaynaklandığı düşünüldü.
FULL TEXT (PDF): 
PDF icon arastirmax-kobay-adrenal-kortekslnin-erken-gec-gebelik-donemlerinde-kiyasli-yapist-morfometrik-isik-mikroskobik-calisma.pdf
  • 2
34-41
  • Turkish

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