Buradasınız

Levotiroksin İntoksikasyonu

Levothyroxine Intoxication

Journal Name:

Publication Year:

Keywords (Original Language):

Abstract (2. Language): 
Levothyroxine is a common agent which is used in thyroid replacement therapy. It has a large scale of symptoms in patients which expose to high doses. Most of the patients remains asymptomatic and only a small amount comes up with symptoms. There haven't been any established trade protocols for levothyroxine intoxication in adults. In this case, we report a 19 year old levothyroxin intoxication patient, required intensive care treatment. Patient had gastrointestinal lavage, activated charcoal, propylthiouracil, propranolol and prednisolone therapy. Patient didn't have any thyrotoxicosis symptoms and discharced.
Abstract (Original Language): 
Levotiroksin, tiroid hormon replasman tedavisinde çok kullanılan bir ajandır. Yetişkinlerde yüksek doz levotiroksin maruziyetine bağlı olarak geniş yelpazede semptomlar ortaya çıkmaktadır. Yetişkin hastaların çoğu asemptomatik seyretmektedir. Uygun tedavi protokolleri hala kesinleşmemiştir. Bu sunumda 19 yaşında levotiroksin intoksikasyonu nedeniyle yoğun bakım ünitesinde takip edilen bir olgu sunuldu. Olguya gastrik lavaj, aktif kömür, propiltiourasil, propranolol ve prednizolon tedavisi uygulandı. Bu olgu, yüksek doz levotiroksin almasına rağmen uygun tedavi ile tirotoksikoz belirtileri gelişmeden hasta düzelerek taburcu edildi.
213-214

REFERENCES

References: 

1.
D.A
. de Luis, A.Duenas, J.Martin, L. Abad, L. Cuellara, R. Aller. Light Symptoms following a High-Dose Intentional L Thyroxine Ingestion Treated with Cholestyramine. Horm Res
2002; 57: 61-63.
2. Lehrner LM, Weir MR. Acute ingestions of thyroid hormones. Pediatrics 1984; 73: 313-317.
3. Gorman RL, Chamberlain JM, Rose SR, Oderda GM. Massive levothyroxine overdose: High anxiety-low toxicity. Pediatrics 1988; 82: 666-669.
4. Shilo L, Kovatz S, Hadari R, Weiss E, Nabriski D,Shenkman L. Massive thyroid hormone overdose: Kinetics, clinical manifestations and management. Isr Med Assoc J 2002; 4: 298¬299.
5. Berkner PD, Starkman H, Person N. Acute 1-thyroxine overdose; therapy with sodium ipodate:evaluation of clinical and physiological parameters. J Emerg Med 1991; 9: 129-131.
6. Lewander WJ, Lecoutre PC, Silva JE.Acute thyroxine ingestions
in pediatric patients. Pediatrics.1989; 84: 262-265.
7. Sara J Matthews. Acute thyroxine overdosage: two cases of parasuicide.The Ulster Medical Journal. 1993; 63:170-173.

Thank you for copying data from http://www.arastirmax.com