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Akciğer Tüberkülozu Tedavisinin Takibinde Serum Ca-125 ve CEA Düzeyleri

Follow Up of Serum Ca125 and CEA Levels For Treatment of Pulmonary Tuberculosis

Journal Name:

  • Fırat Tıp Dergisi

Publication Year:

  • 2006

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Objectives: To determine the levels of Ca125 and CEA those are tumor markers at tuberculosis patients during the treatment. Materials and Methods: In 20 cases that were diagnosed as active pulmonary diagnosis (APT), the serum levels of CA-125 and CEA were measured initially and second and sixth months of the treatment. These results were compared with the results that obtained from 15 inactive pulmonary tuberculosis (IPT) cases and 15 healthy controls. Results: Serum CA-125 levels were higher at APT cases than in IPT cases and controls at the beginning of the treatment (p<0.001, for both). These levels were still higher even if they begin to decrease according to the initial levels at APT cases at 2nd months of the treatment than in IPT and controls were (p<0.01; APT vs. IPT and p<0.005; APT vs. Controls). At 6th months of the treatment, statistically significant differences seen between groups were disappeared (p>0.05). Serum CA-125 levels were decreased as statistically significantly at times of initially, 2nd and 6th months of the treatment (p<0.001). No statistically significant differences were observed from the point view of serum CEA levels in all groups or at duration of treatment. Conclusion: The serum CA-125 levels were high in pulmonary tuberculosis cases and these levels return the normal values with treatment. Thus, we think CA-125 could be used for follow up of tuberculosis treatment. ©2006, Fırat Üniversitesi, Tıp Fakültesi
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Abstract (Original Language): 
Amaç: Tümör belirleyicileri olan CA-125 ve CEA'nın tüberkülozlu hastalarda tedavi süresince serum düzeylerinin saptanması. Gereç ve Yöntem: Aktif akciğer tüberkülozu tanısı konulan 20 olguda, başlangıç ve tedavinin 2. ve 6. aylarında serum CA-125 ve CEA düzeyleri ölçüldü. Ayrıca elde edilen sonuçlar 15 inaktif tüberküloz olgusu ile 15 sağlıklı kontrol olgusundan elde edilen sonuçlarla karşılaştırıldı. Bulgular: Serum CA-125 düzeyleri aktif grupta tedavi başlangıcında hem inaktif hem de kontrol grubundan anlamlı olarak yüksekti (her iki grup için p<0.001). Tedavinin 2. ayında da bu düzeylerin azalmakla birlikte halen yüksek olduğu gözlendi (aktif-inaktif arası p<0.01 ve aktif kontrol arası p<0.005). Tedavinin 6. ayında tüm gruplar arası istatistiksel anlamlılığın kaybolduğu saptandı (p>0.05). Aktif grupta başlangıç, 2. ve 6. aylarda elde edilen değerler karşılaştırıldığında CA-125 düzeylerinin istatistiksel olarak anlamlı olarak tedavi süresi ilerledikçe azaldığı bulundu (p<0.001). Serum CEA düzeylerinde ise hem gruplar arasında hem de tedavi süresince anlamlı bir farkın olmadığı gözlendi (p>0.05). Sonuç: Sonuç olarak akciğer tüberkülozlu hastalarda serum CA-125 düzeylerinin yüksek olduğunu ve tedavi ile bu düzeylerin azalarak normale döndüğünü bu nedenle CA-125'in hastalığın tedavisini takipte kullanılabilecek bir belirteç olduğunu düşünmekteyiz. ©2006, Fırat Üniversitesi, Tıp Fakültesi
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134-138
  • Turkish

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