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Lipoprotein metabolizması hastalıkları ve tedavisine yaklaşım

Lipoprotein metabolism disorders and their treatment

Journal Name:

  • Türkiye Aile Hekimliği Dergisi

Publication Year:

  • 2010
DOI: 
doi:10.2399/tahd.10.038

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Lipoprotein metabolism disorders occupy an important place among cardiovascular diseases. Comorbid situations; such as coronary artery disease, diabetes and metabolic syndrome raise to their importance. Cholesterol and lipoprotein levels have impor¬tant roles in the formation of atherosclerosis. Having knowledge on the lipoprotein metabolism is the main aspect of the treatment plan. Although there are many highly developed drugs to decrease cholesterol levels, the treatment should be arranged according to the patients' needs. Drug intolerance constitutes a problem for the continuity of the treatment. In this review; the latest, long term, large scale randomized trials on this subject have been scrutinized. Important findings from these trials form the base of the treatment plans. The update of National Cholesterol Education Program Adult Treatment Panel-III (NCEP-ATPIII) proto¬cols are closely related with the results of these trials. It can make cholesterol treatment follow-up more effective. As a summary; for primary prevention cardiac diseases for a healthy life consists of keeping LCL cholesterol levels under 130 mg/dl, triglyceride levels under 150 mg/dl, HDL levels for men over 40 mg/dl and for women over 50 mg/dl.
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Abstract (Original Language): 
Lipoprotein metabolizmas ı hastalıkları, kardiyovasküler hastalıklar içerisinde önemli bir yer tutmaktadır. Koroner arter hastalıkları, diyabet ve metabolik sendromla beraber görülmeleri önemlerini daha da arttırmaktadır. Aterosklerozun oluşum döneminde koleste¬rol ve lipoproteinlerin rolü oldukça önemlidir. Lipoprotein metabo¬lizmasının bilinmesi klinik tedavinin oluşturulmasında yardımcı bir unsurdur. Günümüzde kolesterolü düşürmek için çok gelişmiş ilaçların varlığına karşın, hastalara göre tedavinin şekillendirilmesi gerekebilir. Hastaların ilaçlara karşı toleranssızlığı etkin tedavinin devamı için sorun oluşturabilmektedir. Derlememizde bu konuda geniş boyutlu, uzun süreli yapılmış en son randomize çalışmalardan faydalanılmıştır. Bu çalışmalardan elde edilen önemli bulgular tedavilerin şekillendirilmesinde temel oluşturmaktadır. Amerikan Ulusal Kolesterol Eğitim Programı, Erişkin Tedavisi Panel 3'ün (NCEP-ATPIII) güncellenmesi randomize çalışmaların sonuçlarıyla daha yakından ilgilidir. Bu da, daha etkin kolesterol takibi uygula¬malarına yol açacaktır. Özetle, kalp hastalıklarından uzak sağlıklı bir yaşam için öncelikli korunma hedefi: LDL'nin 130 mg/dl'nin altında, trigliseridin 150 mg/dl'nin altında, HDL'nin erkeklerde 40 mg/dl'nin üstünde ve kadınlarda 50 mg/dl'nin üstünde olmasıdır.
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  • 1
38-45
  • Turkish

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