Journal Name:
- Advance Research in Pharmaceuticals and Biologicals
Key Words:
Author Name |
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Abstract (2. Language):
Alprazolam is the most commonly used allopathic remedy for the management of anxiety. Several drugs like Withania,
Valerian & Centella are the leading herbs for the management of anxiety. Magnesium hydroxide when given alone shows
laxative property at all does but if it is given along with Licorice it enhances CNS activity of magnesium salt and produces
hypnosis instead of laxation. Hence in the present study attempts have been made to screen possible synergistic
potentiating anti-anxiety activity of Withania and Alprazolam with Licorice in elevated plus maze and dark light
exploration model. In elevated plus maze model time spent in open arm and number of cross entries were increased
significantly when Withania extract or Alprazolam were given along with Licorice. To conclude, if Withania or
Alprazolam is given in combination with Licorice, there is enhancement of their anti-anxiety activities in mice. The
synergism in the anti-anxiety activity may be due to differences in their mechanism of action or there may be increased
BBB permeability of Withania and Alprazolam by Licorice because of its triterpenoid nature or may be due to inhibition
of certain enzymes responsible for metabolism of Withania and Alprazolam.
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