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QSAR ANALYSIS OF A SERIES OF 1-(2-(2,2,2-TRIFLUOROETHOXY) ETHYL-1 HPYRAZOLO[ 4,3-D]PYRIMIDINES: AS POTENT PHOSPHODIESTERASE 5 (PDE5) INHIBITORS

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2011

Key Words:

Author Name
Abstract (2. Language): 
A series of recently synthesized 1-(2-(2,2,2-Trifluoroethoxy) ethyl-1 H-pyrazolo[4,3-d]pyrimidines as Potent Phosphodiesterase 5 (PDE5) inhibitor was subjected to Quantitative Structure Activity Relationship (QSAR) Analysis . QSAR investigation based on semiemperical AM1 calculations reveals that thermodynamic, electronic & topology parameters are responsible for PDE5 inhibitory activity. Attempt in correlating the derived physiochemical properties with the PDE5 inhibitory activity resulted in some statistically significant QSAR models with good predictive ability. Our study explored some interesting findings for the design of potent new class of PDE5 inhibitors.
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  • 2
139-146
  • Turkish

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