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Analjezik Alımı Sonrası Akut Tübülointerstisyal Nefrit: Dört Olgu Sunumu

Acute Tubulointerstitial Nephritis: Presentation of Four Cases

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2013
DOI: 
DOI 10.5262/tndt.2013.1001.16

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Nonsteroidal anti-inflammatory drugs and paracetamol (acetaminophen) which are analgesic-antipyretic drugs are thought to be safe and are most commonly used in children to control pain and fever. We retrospectively analysed the clinical and laboratory characteristics of four patients who were admitted between 2009-2011 and diagnosed as acute renal failure with a history of analgesic-antipyretic drugs usage. Two of them used flurbiprofen and the other two paracetamol. None of them had any chronic disease. The time between medication and admission to hospital was 3-20 days. Renal biopsy was performed in all patients showing tubulointerstitial inflammation. One patient was given corticosteroid therapy and the other three were treated with hydration only. Renal function tests became normal in 4-9 days. Two of three patients who had proteinuria at admission had normal urinalysis at discharge.
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Abstract (Original Language): 
Analjezik-antipiretik ilaçlardan nonsteroid antiinflamatuvar ilaçlar ve parasetamol (asetaminofen), günlük pratikte güvenli olduğu düşünülen, özellikle çocuklarda ağrı ve ateş kontrolünde sık kullanılan ilaçlardır. 2009-2011 yılları arasında akut böbrek yetmezliği saptanan ve analjezik-antipiretik ilaç kullanım öyküsü olan dört hastanın özellikleri incelendi. Hastalardan ikisi flurbiprofen diğer ikisi parasetamol kullanmıştı. Dört olgunun daha önce bilinen bir hastalığı ve başka ilaç kullanım öyküsü yoktu. Analjezik kullanımı ile hastaneye başvuru arasında geçen süre 3-20 gün arasında idi. Tüm olgulara böbrek biyopsisi yapıldı ve histopatolojik olarak interstisyal inflamasyon gösterildi. Üç olgu intravenöz hidrasyon ile, bir hasta ise steroid ile tedavi edildi. Tedavi ile böbrek fonksiyonları 4-9 gün içinde normale döndü. Proteinürisi olan üç hastanın ikisinde proteinüri düzeldi. Analjezik-antipiretik ilaçlara sekonder akut böbrek yetmezliği ve tübülointerstisyal nefrit gelişimi kısa süreli kullanımlarda da görülebilir; bu yüzden hastaların oral sıvı alımları sorgulanmalı ve böbrek fonksiyonları yakın takip edilmelidir.
FULL TEXT (PDF): 
PDF icon arastrmx_172977_22_pp_106-110.pdf
  • 1
106-110
  • Turkish

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