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FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET OF IMMUNOSUPPRESIVE DRUG

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2013

Key Words:

Author Name
Abstract (2. Language): 
Immunosuppresive drug is used for the immunity suppression in organ transplant so it is required to prepare an immediate release formulation to produce rapid effect during organ transplant. The main objective of the present study is to formulate and evaluate an immediate release tablet of Immunosuppresive drug by wet granulation method. Preformulation studies were performed prior to compression. The tablets were compressed using microcrystalline cellulose, hydroxy propyl cellulose, pregelatinized starch, croscarmellose sodium, talc, magnesium stearate. The fabricated tablets were evaluated for various micromeritic properties like bulk density, tapped density, compressibility index, hausner's ratio, angle of repose and post compression characteristics like thickness, hardness, friability, disintegration time and drug release. The final selection of the formulation (F9) was done on the basis of comparison of disintegration time and in vitro drug release to that of the innovator product. The results of the present study indicate that, the prepared tablets of Immunosuppresive drug could perform therapeutically, with improved efficacy and better patient compliance like that of the Innovator product.
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  • 3
314-332
  • English

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Available Online At www.ijprbs.com
Research Article
Chandra Patni, IJPRBS, 2013; Volume 2(3): 314-332
ISSN: 2277-8713
IJPRBS
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