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NEFROTÎK SENDROM ÎLE SEYREDEN KRONİK LENFOSÎTÎK LÖSEMÎ

CHRONIC LYMPHOCYTIC LEUKEMIA ASSOCIATED WITH NEPHROTIC SYNDROME

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1999

Key Words:

Keywords (Original Language):

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Abstract (2. Language): 
Chronic Lymphocytic Leukemia (CLL) is a hematologic neoplasm characterized by the accumulation mature-appearing lymphocytes in the peripheral blood associated with infiltration of the bone marrow, spleen, lymph nodes and occasionally other organs. Glomerulopathy is a rare complication of CLL The most common clinical presentation of CLL-associated glomerulopathy is the nephrotic syndrome. A 72- year-old woman developed nephrotic syndrome four years after diagnosed Rai Stage- O CLL. Percutaneous renal biopsy showed characteristic features of membranoproliferative glomerulonephritis. At this stage of CLL, treatment with alkylating agents was not recommended. So, we didn't use alkylating agents in our patient. Supportive measures with diuretics, essential aminoacids with ketoanalogues, dipyridamole, acetly salicylic acid were undertaken. Available evidence suggests that nephrotic syndrome associated with CLL is not fortuitous and often related to immun-complex disease.
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Abstract (Original Language): 
Kronik lenfositik lösemi (KLL), matürgörünüşdeki lenfositlerin kemik iliği, dalak, lenf nodları, nadiren diğer organlarda infütrasyonu ve periferik kanda birikimi ile karakterize bir hematolojik neoplazmdır. Glomerulopati KLL'nin nadir bir komplikasyonudur. KLL ile bir ar ada olan glomerulopatinin en yaygın klinik görüntüsü nefrotiksendromdur. Rai Stage-0KLL tanısı olan 72 yaşında bir bayan hastada dört yıl sonra nefrotik sendrom gelişmiştir. Per kut an böbrek biyopsisinde membranoproliferatif glomendonefrit saptanmıştır.Bu dönemdeki KLL 'de alkilleyici ajanlarla tedavi önerilmemektedir. Bu nedenle hastamızda alkilleyici ajanları kullanılmamış; diüretik, esansiyel aminoasid-keto analogları, dipridamol, asetil solistlik asit ile destek tedavisi uygulanmıştır. KLL ve glomerulopati birlikteliğinin tesadüfi olmadığı bilinmekte olup, bir immün kompleks hastalığı ile ilintilendirilmektedir.
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  • 2
91-93
  • Turkish

REFERENCES

References: 

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