“Role of lipid peroxidation and antioxidant status in pathogenesis of Pre-eclampsia.”

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However the balance can be lost because of the
overproduction of free radicals by exposure to sources that
overwhelm the antioxidant defenses, or by inadequate
intake of nutrients that contribute to the oxidative stress in
pre-eclampsia [15]. The placentally derived endothelial
disturbing factors like lipid peroxides could be a possible
cause in the pathogenesis of pre-eclampsia[16].
This association may be significant in understanding the
pathological process of pre-eclampsia and may help in
developing strategies for prevention and early diagnosis of
pre-eclampsia. Thus, estimation of MDA levels, vitamin E
may have a predictive role in the assessment of the extent of
endothelial damage in pre-eclampsia and may help patient
by preventing or foreseeing the effects of complications in
pre-eclampsia. As oxidative stress can provoke endothelial
dysfunction, the pregnant subjects should be supplemented
with antioxidants to prevent overwhelming of oxidative
stress.
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