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KALSİTONİNİN ALVEOLER KEMİK İYİLEŞMESİ ÜZERİNE ETKİSİNİN DENEYSEL ARAŞTIRILMASI

AN EXPERIMENTAL INVESTIGATION OF, THE EFFECT OF CALCITONIN ON ALVEOLAR BONE HEALING

Journal Name:

  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 1996

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Calcitonin, a hormone that regulates the bone apposition and resorption in the body, is secreted from the parafollicular cells of the thyroid gland and has an effect, opposite to the parathormone, on the blood calcium level. It decreases the blood calcium level and inhibits the calcium metabolism. In this study, tooth extractions were performed in 20 Wistar-albino rats ofivhich 10 were in the study and the reamining, in the control group and the effect of calcitonin on the early stage of bone healing were evaluated. An increase in the osteoblastic activity together with dense new bone formation were observed histologically on the bone surface adjacent to the extraction sites in all the rats of the experimental group.
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Abstract (Original Language): 
Vücutta kemik yapım ve yıkım olaylarını düzenleyen hormonlardan biri olan kalsitonin, Landa tiroid bezinin parafoliküler hücrelerinden salgılanır ve kan kalsiyum seviyesini parathormonun tersi yönünde etkiler. Ayrıca kan kalsiyumu seviyesini düşürür ve kemikler üzerindeki etkisiyle kalsiyum metabolizması inhibe eder. Bu çalışmada 10'u deney, 10'u kontrol grubu olmak üzere 20 adet Wİstar-albino sıçanda kalsitonblin diş çekimi sonrası erken dönemde kemik yapımı üzerine etkisi araştırıldı. Deney grubunu oluşturan bütün sıçanlarda alveol kemiğinin çekim boşluğuna bakan yüzeyinde histolojik olarak osteoblastik aktivitede artış ile birlikte yoğun yeni kemik yapımı alanları izlendi.
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REFERENCES

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