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FORMULATION DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLET OF METFORMIN HYDROCHLORIDE

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The objective of the present study was to develop once-daily sustained-release matrix tablets of metformin HCl, antidiabetic agent which is prescribed for the treatment of noninsulin dependent diabetes mellitus. The tablets were prepared by the non-aqueous wet granulation method. Isopropyl alcohol solution of polyvinylpyrrolidone (PVPK30) was used as granulating agents along with hydrophilic matrix materials like hydroxypropyl methylcellulose (HPMC) and locust bean gum (LBG). The tablets were subjected to thickness, weight variation test, drug content, hardness, friability, and in vitro release studies. All the tablet formulations showed acceptable pharmacotechnical properties and complied with in-house specifications for tested parameters. The results of dissolution studies indicated that formulation M5 (HPMC: LBG, 200:30 mg) could extend the drug release up to 8 hours. The successful formulation of the study, exhibited satisfactory drug release (M5) was compared with the marketed formulation (Obimet SR™) and showed very close to release profile which suggests sustained release profile.
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